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Affinity of cladinosolides erythromycin and ketolide ABT-773 for E. coli ribosomes carrying different mutations in 23S rRNA
| Mutant or wild type |
Kd (nM)a
|
KdEry/KdABT-773 ratio | |
|---|---|---|---|
| Erythromycin | ABT-773 | ||
| Wild type | 7.8 | 1.3 | 6.0 |
| U754A | 6.7 | 2.8 | 2.4 |
| U2609C | 5.1 | 7.9 | 0.6 |
| A2058G | NDb | 1,500 | |
An average error in Kd measurements was 20%.
ND, not determined.
