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. 2022 Jul;74(3):825–875. doi: 10.1124/pharmrev.121.000564

Fig. 11.

Fig. 11

Estimated CO saturation levels of sGC in the presence of various levels of COHb in a binary system. Solid lines in the left panel and dashed lines in the right panel represent scenarios at COHb concentrations of 1%, 6%, and 14%, respectively; scales are different from that of Fig. 8 due to the low affinity of sGC for CO and the need to expand the low-saturation level region to present a meaningful figure. The graphs were generated based on eq. 1 by using Mathematica 12 (codes provided in Supplemental Appendix 2).