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Structural changes of Helix-X induced by heme a3-CO binding. The heme a and heme a3 bind to the imidazole axial ligands of H378 and H376, respectively. CO binds to the heme a3, which induces conformational changes to the helix domain, allowing for the interaction of S382 and the OH group on the farnesyl side chain of the oxidized heme a.
