Fig. 28.
CO distribution is dependent on the dynamic change of the ratio between high affinity and low affinity of COHb. (A) A brief description of the idea of the shifting distribution of CO from the cardiovascular circulation to peripheral tissues when O2 pressure is low and Hb largely exists in the low-affinity T state because of the change in pH and O2 partial pressure, among other factors. (B) A detailed description of the processes leading to CO redistribution depending on O2 partial pressure.