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Mitofusin activators used in these studies. (top) Chimera C is the prototype for first generation triazolurea class of mitofusn activators that are not suitable for in vivo studies. (Middle) trans-MiM111 and (lower) CPR1-B are second generation phenylhexanamide mitofusin activators that have stereoisomer-specific activity and can be used in vivo.
