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. 2022 Nov;383(2):137–148. doi: 10.1124/jpet.122.001332

Fig. 5.

Fig. 5.

Dose-dependent effects of mitofusin activation on mitochondrial motility and neuromuscular integrity in CMT2A mice. (A) Mitochondrial motility in CMT2A mouse sciatic nerve axons. (left) Representative kymographs showing motile mitochondria in neuronal axons 6 hours after indicated oral dosing of MiM111; mitochondria appear black. Raw data on top; bottom panels are retracings emphasizing motile mitochondria (blue is antegrade and red is retrograde transport). (right) Quantitative group mean mitochondrial motility data. Each marker represents a different neuronal axon from 2–3 mice per condition. * = P < 0.05 versus WT, # = P < 0.05 versus vehicle by ANOVA. (B and C) Effects of orally administered MiM111 given once daily on CMT2A mouse Rotarod latency (B) and CMAP amplitude (C). * = P < 0.05 versus baseline, # = P < 0.05 versus vehicle at same time point, by 2-way ANOVA.