TABLE 1.
Calculated data from Fig. 2 showing comparative activities of small molecule mitofusin activators for mitochondrial fusion versus mitochondrial motility
Fusogenicity was measured in Mfn2 null MEFs. Motility was measured in MFN2 T105M expressing mouse DRGs. Data are means (95% confidence interval). All concentration-response relations were indexed to independent trans-MiM111 studies.
| Compound | Fusogenicity | Motility | ||||
|---|---|---|---|---|---|---|
| % filamentous mito | Mito aspect ratio | % motile mito | ||||
| EC50 (nM) | Emax (%) | EC50 (nM) | Emax (%) | EC50 (nM) | Emax (%) | |
| cis-MiM111 | NA | 38 (32–45) | ND | ND | ND | ND |
| trans-MiM111 | 3.6 (2.1–6.0) | 93 (82–104) | 3.2 (2.1–4.7) | 89 (82–96) | 3.3 (2.0–5.3) | 96 (86–105) |
| CPR1-A | NA | 14 (8.2–19.7) | ND | ND | ND | ND |
| CPR1-B | 3.3 (2.0–5.1) | 87 (79–95) | 4.9 (3.4–6.9) | 96 (89–104) | 11.2 (5.8–21) | 99 (82–115) |
NA, not applicable; ND, not determined.