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Interactions between prostaglandins and the renin-angiotensin system (RAS) in the kidney. Firstly, in the vasculature, prostaglandin E2 (PGE2) and I2 (PGI2) cause vasodilatation, counteracting the vasoconstriction of angiotensin (Ang) II. Secondly, in the kidney cortex, PGE2 is produced when hypovolemia occurs and subsequently induces renin production by juxtaglomerular cells. Finally, in the kidney medulla, PGE2 counteracts the effects of Ang II on sodium retention.
