TABLE 1.

(Pro)renin and the (pro)renin receptor [(P)RR] in the collecting duct: synthesis and effects, including effects that involve the soluble s(P)RR

Synthesis
(Pro)renin	↑ after Ang II (Prieto-Carrasquero et al., 2004)
	↑ after low sodium (Rohrwasser et al., 1999)
	↑ after hyperglycemia (Kang et al., 2008)
(P)RR	↑ after Ang II (Gonzalez et al., 2011, 2014b; Wang et al., 2014)
	↑ after low sodium (Quadri and Siragy, 2014)
	↑ or = after hyperglycemia (Ichihara et al., 2008; Matavelli et al., 2010)
Effects (P)RR
Water transport	↑ via Ang II or Ang II–independent (Song et al., 2013; Ramkumar et al., 2015; Lu et al., 2016b; Wang et al., 2016)
Sodium reabsorption	↑ partly via Ang II (Ramkumar et al., 2015, 2016b, 2018; Lu et al., 2016a,b; Quadri and Siragy, 2016)
Fibrosis	↑ Ang II–independent (Reyes-Martinez et al., 2019)
Urinary acidification	↑ (pro)renin-independent (Trepiccione et al., 2016)
Effects s(P)RR
Water transport	↓ in a polyuria model (Lu et al., 2016b; Wang et al., 2019)
Sodium reabsorption	↑ via ENaC (Wang et al., 2020; Feng et al., 2021)
Blood pressure	↑ during Ang II infusion (Ramkumar et al., 2021)