TABLE 8.

Summary of preclinical efficacy of group III mGlu receptor allosteric modulators in stress-related deficits

Receptor	Type	Compound	Behavioral Effect	References
mGlu4	PAM	PHCCC	Antidepressant-like effects in rats;a intra-BLA administration elicits anticonflict effects in rats subjected to the Vogel conflict testb	(See footnotes.)
		ADX88178	Reduced duration of immobility in the FST; attenuated conditioned freezing in the acquisition phase of the fear conditioning	Kalinichev et al., 2014
		Lu AF21934	Anxiolytic, but not antidepressant-like, effects as measured by SIH, four-plate, marble-burying, and Vogel’s conflict tests	Sławińska et al., 2013b
mGlu7	NAM	ADX71743	Dose-dependent reduction in the number of buried marbles and increasing open arm exploration in EPM and marble-burying assays	Kalinichev et al., 2013

^aKłak et al., 2007.

^bStachowicz et al., 2004.

BLA, basolateral amygdala