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a. Commercially available 18 (C276–1187) and 19 (D052–0147) shown to inhibit P.falciparum; b. Pyrimidine triazinediones 19, 22, 23 lead to radical intermediates 21 and H2O2 release; c. Strategy of replacing triazine with pyridazine to prevent first reduction step shown in 7b.
