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. Author manuscript; available in PMC: 2023 Mar 24.
Published in final edited form as: J Med Chem. 2022 Mar 3;65(6):4403–4423. doi: 10.1021/acs.jmedchem.1c01577

Table 1.

Structural classification of PfGluPho inhibitors identified by the Bode group; Numbers in parenthesis (as taken from the original paper).

Compounds Class 1
pyrimidinones 11		 Class 2
quinazolinones 12		 Class 3
chromenones 13		 Class 4
sulfonamides 14		 PfGluPho IC50 (μΜ)
recomb.		 PfGluPho IC50 (μΜ)
cult.
graphic file with name nihms-1833244-t0017.jpg graphic file with name nihms-1833244-t0018.jpg graphic file with name nihms-1833244-t0019.jpg graphic file with name nihms-1833244-t0020.jpg
11a (CB64) graphic file with name nihms-1833244-t0021.jpg 19.9 ± 7.2 -
11b (CB62) graphic file with name nihms-1833244-t0022.jpg 11.6 ± 1.0 -
11c (CB61) graphic file with name nihms-1833244-t0023.jpg 5.1 ± 3.2 -
11d (CB22) graphic file with name nihms-1833244-t0024.jpg 4.6 ± 2.4 -
12a (CB104) graphic file with name nihms-1833244-t0025.jpg 7.6 ± 4.0 -
12b (CB70) graphic file with name nihms-1833244-t0026.jpg 4.5 ± 1.6 -
13a (CB103) graphic file with name nihms-1833244-t0027.jpg 1.5 ± 0.4 0.97 ± 0.15
14a (CB83) graphic file with name nihms-1833244-t0028.jpg 22.0 ± 8.0 5.3 ± 2
14b (CB90) graphic file with name nihms-1833244-t0029.jpg >30 3.9 ± 0.14