TABLE 3.
Adjusted Associations Between Neuroendocrine and Inflammatory Factor Scores and FEPT Performance in People With HIV
| Factor | Total Accuracy, B (SE) | Neutral, B (SE) | Sad, B (SE) | Anger, B (SE) | Fear, B (SE) | Happy, B (SE) |
|---|---|---|---|---|---|---|
| Early life trauma (versus unexposed) | — | — | −0.13 (0.09) | −0.12 (0.08) | — | — |
| 1: Proinflammatory cytokines (TNF-α, IL-1β, IL-8, IL-6) | −0.03 (0.03) | −0.01 (0.04) | 0.02 (0.04) | −0.07 (0.04)† | −0.02 (0.03) | −0.04 (0.04) |
| 2: Myeloid migration (MCP-1, MMP-9) | −0.09 (0.03)** | −0.08 (0.04)† | −0.11 (0.04)* | −0.10 (0.04)* | −0.07 (0.03)* | −0.09 (0.04)* |
| 3: OT/CRP (OT, CRP) | — | — | −0.05 (0.04) | −0.04 (0.04) | — | — |
| 4: Chemokines regulating immune cell trafficking (MIG, IP-10) | 0.03 (0.03) | 0.06 (0.04) | −0.04 (0.04) | 0.05 (0.04) | 0.03 (0.03) | 0.03 (0.03) |
| 5: HPA axis hormones (AVP, cortisol) | −0.04 (0.03) | — | −0.02 (0.04) | −0.01 (0.04) | −0.04 (0.03) | −0.01 (0.03) |
FEPT = Facial Emotion Perception Test; B = unstandardized β coefficients; SE = standard error; TNF-α = tumor necrosis factor α; IL = interleukin; MCP-1 = monocyte chemotactic protein-1; MMP-9 = matrix metalloproteinase-9; OT = oxytocin; CRP = C-reactive protein; MIG = monokine induced by interferon; IP-10 = interferon γ–induced protein; HPA = hypothalamic-pituitary-adrenal.
The dash (—) indicates that the factor was a biological moderator of the early life trauma–performance association at p < .10.
* p < .05.
** p < .01.
*** p < .001.
†p > .05 and p < .10.