Table 3.
Univariate and Multivariate Cox Regression Analyses of Risk Factors for Overall Survival
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age, y (≤/>50) | 0.418 | 0.220–0.795 | 0.008 | |||
| Gender (male/female) | 1.287 | 0.648–2.554 | 0.471 | |||
| Hepatitis (yes /no) | 1.217 | 0.649–2.283 | 0.541 | |||
| ALT, U/L, (>/≤50) | 2.090 | 0.969–4.507 | 0.060 | |||
| AST, U/L, (>/≤40) | 1.289 | 0.689–2.413 | 0.427 | |||
| ALB, g/L, (>/≤35) | 0.417 | 0.171–1.015 | 0.054 | |||
| TBIL, umol/L, (>/≤17.1) | 1.379 | 0.601–3.163 | 0.448 | |||
| CA19-9U/mL, (>/≤100) | 1.426 | 0.762–2.668 | 0.268 | |||
| Largest tumour size (>/≤10 cm) | 1.15 | 0.615–2.152 | 0.662 | |||
| Tumor number (>1/1) | 1.546 | 0.783–3.053 | 0.209 | |||
| Macrovascular invasion (yes/no) | 1.233 | 0.661–2.300 | 0.509 | |||
| Lymph node metastasis (yes/no) | 3.316 | 1.521–7.229 | 0.003 | 3.112 | 1.372–7.056 | 0.007 |
| TNM stage (III–IV /II) | 3.311 | 1.460–7.510 | 0.004 | |||
| CRP (1/0) | 8.405 | 3.549–19.906 | <0.001 | 6.032 | 2.467–14.752 | <0.001 |
| PLR (1/0) | 3.618 | 1.772–7.387 | <0.001 | 2.433 | 1.151–5.145 | 0.020 |
| NLR (1/0) | 2.530 | 1.324–4.838 | 0.005 | |||
| LCR (1/0) | 5.695 | 2.622–12.368 | <0.001 | |||
| LMR (1/0) | 2.336 | 1.209–4.512 | 0.012 | |||
| SII (1/0) | 3.751 | 1.895–7.426 | <0.001 | |||
| CAR (1/0) | 6.731 | 2.968–15.265 | <0.001 | |||
| PNI (1/0) | 3.777 | 1.834–7.779 | <0.001 | |||
| GPS | ||||||
| 0 | Reference | Reference | Reference | |||
| 1 | 3.564 | 1.625–7.815 | 0.002 | |||
| 2 | 6.350 | 2.009–20.069 | 0.002 | |||
| PI | ||||||
| 0 | Reference | Reference | Reference | |||
| 1 | 4.485 | 1.817–11.070 | 0.001 | |||
| 2 | 9.148 | 3.072–27.238 | <0.001 | |||
Note: P-value < 0.05 is statistically significant in both univariate and multivariate analyses.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, albumin; TBIL, total bilirubin; TNM, tumour-node-metastasis; CRP, C-reactive protein; PLR, platelet-to-lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio; LCR, lymphocyte-to-C-reactive protein ratio; LMR, lymphocyte-to-monocyte ratio; SII, systemic immune-inflammation index; CAR, C-reactive protein-to-albumin ratio; PNI, prognostic nutritional index; GPS, Glasgow Prognostic Score; PI, prognostic index.