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. 2022 Oct 10;16:3297–3309. doi: 10.2147/OPTH.S373538

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© 2022 Kedarisetti et al.

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Representative Illustration of Ciliary Neurotrophic factor (CNTF)-secreting implant (A) using Encapsulated cell technology. The implant consists of genetically bioengineered CNTF secreting cells enclosed in a semipermeable membrane. It is surgically anchored at the pars plana using a suture clip (B). The cross section image shows the membrane that allows nutrients to diffuse in and CNTF agent to diffuse out while not allowing immune cells to reach the CNTF secreting cells (C).