. 2022 Oct 10;16:3297–3309. doi: 10.2147/OPTH.S373538

Table 2.

Natural History of MacTel 2

Study	Number of Patients And Duration of Disease	Visual Acuity Parameters	Salient Features
Marsonia et al, 2021³	82 eyes of 47 patients, 4.5 years	Most patients maintained BCVA from logMAR 0.25 ± 0.25 to 0.46 ± 0.42	Major cause of poor vision observed was SNV (active in 10.98% and scarred in 7.32%), foveal atrophy (10.98%) and central pigmented plaques (3.66%). The incidence of sight-threatening lesions like SNV (10.6%)
Clemons et al, 2010⁵	310 patients, 3.2 years	BCVA was 20/20 or better in 16% of these eyes	More than half of the patients had ≥20/32 in their better eye over a 3.2 year follow up
Shukla et al, 2012⁴⁵	203 eyes of 103 patients, 2.5 years	Mean logMAR BCVA declined from 0.35 to 0.43 by 2.5 years (P < 0.0001)	14% incidence of SNV. Final mean logMAR BCVA was 0.61 (20/80) in the eyes with SNV and 0.40 (20/50) in eyes without SNV
Peto et al, 2017⁵⁰	507 participants, 4.2 years	BCVA decreased 1.07 ± 0.05 letters per year. Of all eyes, 15% lost ≥15 letters after 5 years	The rate of BCVA loss was significantly higher in eyes with central EZ loss at baseline (−1.40 ± 0.14 letters, P < 0.001)