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Interim analysis of OS. Kaplan-Meier estimates of overall survival at the interim analysis are (A) shown for all patients and (B) patients with detectable ESR1 mutation. The differences in overall survival in this interim analysis were not statistically significant on the basis of the allocated two-sided alpha level of .0001. Analysis was performed on the intention-to-treat population. HR, hazard ratio; NS, nonsignificant; OS, overall survival; SOC, standard of care.
