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. 2022 Sep 30;2022:7958542. doi: 10.1155/2022/7958542

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Copyright © 2022 Tiechun Zhang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The effects of GEC1 in blood CECs on NLRP3 inflammasome production after AMI. (a) Venn diagram showing 23 DEGs shared by immune-related gene cluster and inflammation-related gene cluster in AMI. (b) Heatmaps of the 23 DEGs related to immune and inflammation in AMI. (c) The expression of NLRP3 in blood after AMI is based on GSE66360 database. (d) Flow cytometric analysis of the expression of NLRP3 in blood monocytes after AMI. (e) Western blot analysis shows that the expression of NLRP3 and corresponding inflammatory factors were significantly increased in blood CECs after AMI, which was markedly inhibited by shGEC1. (a) p < 0.05 compared with the normal control group, (b) p < 0.05 compared with the AMI group.