. 2022 Oct 12;16:3493–3555. doi: 10.2147/DDDT.S377921

Table 1.

Brief Summary of New Compounds

NO	Compounds	Fungal Strain	Place	Biological activity	Ref.
Alkaloids
1	Pseudofischerine	Neosartorya pseudofischeri	Angthong Province, Thailand	–	[10]
2–3	Peneciraistins E-F	Penicillium raistrickii	Shandong Province, China	-	[11]
4*	Exopisiod	Exophiala pisciphila strain PHF-9	Yunnan Province, China	Induction of apoptosis	[12]
5*	Waikialoid A	Aspergillus sp.	Honolulu, Hawaii	Suppresses Hyphal Morphogenesis and Inhibits Biofilm Development in Pathogenic Candida albicans	[13]
6	Effusin A	Aspergillus effuses H1-1	Fujian Province, China	Antitumor activity	[14]
7*	Dihydrocryptoechinulin D	Aspergillus effuses H1-1	Fujian Province, China	Antitumor activity	[14]
8*	Dihydroneochinulin B	Aspergillus effuses H1-1	Fujian Province, China	Cytotoxic activity	[15]
9	Unnamed	Neosartorya fischeri KUFC 6344	Thailand	-	[16]
10*	3-deoxo-4b-deoxypaxilline	Penicillium camemberti OUCMDZ-1492	Hainan Province, China	Antiviral activity against the H1N1 virus	[17]
11*	4a-demethylpaspaline-4a-carboxylic acid
12*	4a-demethylpaspaline-3,4,4a-triol
13	2’-hydroxypaxilline
14*	9,10-diisopentenylpaxilline
15*	(6S,7R,10E,14E)-16-(1H-Indol-3-yl)-2,6,10,14-tetramethylhexadeca-2,10,14-triene-6,7-diol
16, 17*, 18–21	Asperdiazapinones A-F	Aspergillus sp. PSU-RSPG185	Suratthani Province, Thailand	Antimalarial activity	[18]
22–23, 24*	Mangrovamides A-C	Penicillium sp. SYFz-1	Hainan Province, China	Moderate acetylcholinesterase inhibitory activity	[19]
25, 26, 27*	Rubrumazines A-C	Eurotium rubrum MA-150	Andaman Sea coastline, Thailand	Brine shrimp lethality	[20]
28	Penilline A	Penicillium sp. SCSIO 05705	Chinese Antarctic station	-	[21]
29	Isopenilline A
30	Penilline B
31–32, 33*	Kumbicins A-C	Aspergillus kumbius FRR6049	Southern Queensland, Australia	Antitumour activity; Antimicrobial activity	[22]
34, 35	Asterriquinols E-F	Aspergillus sp.CBS-P-2	Jilin Province, China	Inhibitory activities against LPS-induced NO production in microglia BV-2 cells (34, 35); Cytotoxicity (34*)	[23]
36–37	Cyclopiamines C-D	Penicillium sp. CML 3020	Atlantic Forest, Brazil	-	[24]
38, 39, 40, 41, 42, 43, 44, 45, 46, 47	Tolypocladins A-J	Tolypocladium sp. XL115	Hunan Province, China	Cytotoxic activity (38); Antibacterial activity (38, 39, 45); Antifungal activity (38, 40, 41, 42, 43, 44, 46, 47)	[25]
48, 49	Chaetomadrasins A-B	Chaetomium madrasense 375	Sinkiang Province, China	Cytotoxicity	[26]
50	Paraherquamide J	Penicillium janthinellum HK1-6	Hainan Province, China	-	[27]
51–52	Tryptoquivalines W-X	Aspergillus terreus FS107	Top of Mauna Kea, Hawaii	-	[28]
53*, 54–55	Cytochalasins Z_24-26	Eutypella sp. D-1	London Island of Kongsfjorden, Arctic	Cytotoxicity	[29]
56	Aspergilluchalasin	Aspergillus sp. PSU-RSPG185	Surat Thani Province, Thailand	-	[30]
57*, 58	Iizukines C-D	Aspergillus iizukae	Shandong Province, China	Cytotoxicity	[31]
59	MBJ-0030	Stachybotrys sp. f23793	Shizuoka prefecture, Japan	-	[32]
60	MBJ-0031
61	MBJ-0032
62, 63, 64, 65	Pycnidiophorones A-D	Pycnidiophora dispersa	Hebei Province, China	Cytotoxicity	[33]
66*	Clonorosin A	Clonostachys rosea	Bank of the Yellow River in Lanzhou, Gansu, China	Active (66*) against Fusarium oxysporum	[34]
67	Clonorosin B	Clonostachys rosea	Bank of the Yellow River in Lanzhou, Gansu, China	Active (66*) against Fusarium oxysporum	[34]
68, 69, 70, 71, 72, 73	Gymnastatins T-Y	Gymnascella dankaliensis	Giza pyramids, Egypt	Cytotoxicity	[35]
74*	Dankastatin D	Gymnascella dankaliensis	Giza pyramids, Egypt	Cytotoxicity	[35]
75	N-[4-hydroxy-3-prenyl-benzoyl]-L-threonine	Curvularia inaequalis strain HS-FG-257	Heilongjiang Province, China	-	[36]
76	N-[2,2-dimethyl-2H-chromene-6-carbonyl]-L-threonine	Curvularia inaequalis strain HS-FG-257	Heilongjiang Province, China	-	[36]
77	(5S)-3,4,5,7-tetramethyl-5,8-dihydroxyl-6(5H)-isoquinolinone	Penicillium sp. H9318	Malaysia	-	[37]
78	3,8-Diacetyl-4-(3-methoxy-4,5-methylenedioxy)benzyl-7-phenyl-6-oxa-3,8-diazabicyclo[3.2.1]octane	Neosartorya pseudofischeri	Angthong Province, Thailand	-	[10]
79	Fusaravenin	Fusarium avenaceum SF-1502	Gansu Province, China	-	[38]
80*	(-) Benzomalvins E	Penicillium sp. SYPF 8411	Xinjiang Uygur Autonomous Region, China	Indoleamine 2.3-dioxygenase (IDO) inhibitor	[39]
81	Tryptoquivaline V	Neosartorya pseudofischeri	Chiang Mai forest, Thailand	-	[40]
82	Brasiliamide G	Neosartorya pseudofischeri	Chiang Mai forest, Thailand	-	[40]
83	Talarodone A	Co-culture of Talaromyces pinophilus and Paraphaeosphaeria sp.	Miyazaki Prefecture, Japan	-	[41]
84–86	Asperidines A-C	Aspergillus sclerotiorum PSU-RSPG178	Surat Thani Province, Thailand	-	[42]
87	Iizukine E	Aspergillus iizukae	Shandong Province, China	-	[31]
88	Methyl (2Z,3E,5E,7E,9E)-4,10-dimethyl-11-(2,5-dioxopyrrolidin-3-yl)-2-(2-hydroxyethylidene)-11-oxoundeca-3,5,7,9-tetraenoate	Aspergillus sp. OUCMDZ-1914	Hainan Province, China	-	[43]
89*	Virgaricin B	Virgaria boninensis FKI-4958	The Bonin Islands, Tokyo, Japan	Antibacterial activity	[44]
90*	Paecilomide	Paecilomyces lilacinus	UFMG, MG, Brazil	Acetylcholinesterase inhibitory activity	[45]
91	Clonostalactam	Clonostachys rosea	Banyumas, Indonesia	-	[46]
92*	Trichothioneic acid	Trichoderma virens FKI-7573	Obihiro, Hokkaido, Japan	Hydroxyl radical-scavenging; Singlet oxygen-quenching activity	[47]
Terpenoids and steroids
93*, 94	Fudecadiones A-B	Penicillium sp. BCC 17468	Khao Yai National Park, Nakhon Ratchasima, Thailand	Anticancer activity	[48]
95*	8α-Hydroxyroridin H	Myrothecium sp. GS-17	Gansu Province, China	Antifungal Activity	[49]
96*	Myrothecin A	Myrothecium sp. GS-17	Gansu Province, China	Antifungal Activity	[49]
97, 98	Penicibilaenes A-B	Penicillium bilaiae MA-267	Hainan Province, China	Antifungal activity	[50]
99*, 100	Penicilleremophilanes A-B	Penicillium copticola PSU-RSPG138	Surat Thani Province, Thailand	Cytotoxic activity; Antimycobacterial activity; Antimalarial activity	[51]
101*	Aspergiketone	Aspergillus fumigatus	Shandong Province, China	Cytotoxicity	[52]
102*, 103–106	Ochraceopones A-E	Aspergillus ochraceopetaliformis SCSIO 05702	Chinese Antarctic station	Antiviral activity	[53]
107*	13-Hydroxy-3,8,7(11)-eudesmatrien-12,8-olide	Eutypella sp. 1–15	Fujian Province, China	Antibacterial activity; Anticancer activity	[54]
108	13-Hydroxy-3,5,8,7(11)-eudesmatetraen-12,8-olide
109	2-One-13-hydroxy-3,5,8,7(11)-eudesmatetraen-12,8-olide
110	8,13-Dihydroxy-3,7(11)-eudesmadien-12,8-olide
111	3β-hydroxy-β-acorenol	Fusarium proliferatum AF-04	Green Chinese onion	-	[38]
112	Cyclonerotriol B	Fusarium avenaceum SF-1502	-	-	[38]
113–114, 115*	Trichodermapenes A-C	Trichoderma reesei PSU-SPSF013	Narathiwat Province, Thailand	Antifungal activity	[55]
116–118	Dictyosporins A-C	Dictyosporium digitatum	Herod, Illinois, USA	-	[56]
119	Trichocitrinovirene A	Trichoderma citrinoviride PSU-SPSF346	Sirindhorn Peat Swamp Forest, Narathiwat Province, Thailand.	-	[57]
120	Trichocitrinovirene B	Trichoderma citrinoviride PSU-SPSF346		-	[57]
121	Unnamed	Aspergillus calidoustus	Dianchi Lake, Yunnan Province.China	-	[58]
122	Unnamed
123	Unnamed
124	Unnamed
125	Unnamed
126	Unnamed
127	Unnamed
128*	Sartorypyrone A	Neosartorya fischeri KUFC 6344	Thailand	Anticancer activity	[16]
129, 130	Libertellenones G-H	Eutypella sp. D-1	London Island of Kongsfjorden, Arctic	Antibacterial activity (129); Anticancer activity (130)	[59]
131	4b-deoxy-1’-O-acetylpaxilline	Penicillium sp. CM-7	Yunnan Province, China	-	[60]
132	4b-deoxypenijanthine A	Penicillium sp. CM-7	Yunnan Province, China	-	[60]
133, 134, 135, 136, 137*	Libertellenones O-S	Eutypella sp. D-1	London Island of Kongsfjorden, Arctic	Cytotoxic activity (133-139); Inhibit the activity of NF-κB inhibitory effects on nitric oxide production induced by lipopolysaccharide (138, 139)	[61]
138, 139	Eutypellenones A-B	Eutypella sp. D-1	London Island of Kongsfjorden, Arctic		[61]
140, 141	Libertellenones M-N	Eutypella sp. D-1	London Island of Kongsfjorden, Arctic	Cytotoxicity (140, 141); Antibacterial activity (140*)	[62]
142, 143, 144, 145, 146*, 147, 148	Dongtingnoids A-G	Penicillium sp. DT10	Hunan Province, China	Seed-germination-promoting activity	[63]
149*, 150	Tolypocladins K-L	Tolypocladium sp. XL115	Hunan Province, China	Antifungal activity (149*)	[64]
151*	Trichodermanene	Trichoderma reesei PSU-SPSF013	Narathiwat Province, Thailand	Antifungal activity	[55]
152	4,25-dehydrominiolutelide B	Penicillium sp. MA-37	Hainan Province, China	-	[65]
153	4,25-dehydro-22-deoxyminiolutelide B
154	Isominiolutelide A
155, 156, 157, 158*, 159	Purpurogenolides A-E	Penicillium purpurogenum MHz 111	Heilongjiang Province, China	Inhibition of nitric oxide production	[66]
160, 161, 162–163	Unnamed	Penicillium sp.	Liaoning Province, China	Cytotoxic activity (160, 161); Antibacterial activity (160*)	[67]
164	Terretonin M	Aspergillus terreus TM8	A hot (~50 °C) desert place, South Egypt	-	[68]
165*	Δ¹²-19-dehydroxyarthripenoid A	Bipolaris zeicola	Hubei Province, China	Significant inhibitory effect against concanavalin A (ConA)-induced T lymphocyte proliferation (165, 166, 169, 170, 173); Cytotoxic activity (165, 166, 168)	[69]
166*	12,19-didehydroxy-arthripenoid A
167	Tetrahydrofuran-3-epi-cochlioquinone A
168*	Isotetrahydrofuran-3-epi-cochlioquinone A
169*	19-dehydroxy-arthripenoid A
170*	Δ²-19-dehydroxy-arthripenoid A
171	4-acetoxy-isocochlioquinone D
172	4-acetoxy-31α-methoxy-isocochlioquinone D
173*	19-dehydroxyl-31-keto-3-epi-arthripenoid A
174	Acremine T	Acremonium persicinum SC0105	Guangdong Province, China	Cytotoxicity	[5]
175, 176,177–178	Bisacremines A-D	Acremonium persicinum SC0105	Guangdong Province, China	Cytotoxicity	[5]
179–180,181*	Bisacremines E-G	Acremonium persicinum SC0105	Guangdong Province, China	Anti-inflammatory activity	[70]
182	Asperanstinoid A	Aspergillus calidoustus	Dianchi Lake, Yunnan Province.China	Cytotoxicity (185*) against the HL- 60 and SU-DHL-4 tumor cell lines.	[71]
183	Asperanstinoid B
184	Asperanstinoid C
185*	Asperanstinoid D
186	Asperanstinoid E
187	Bipolaquinone A	Bipolaris zeicola	Mo Mountain of East Lake, Wuhan City of Hubei Province, China,	Inhibitory activity (188, 189, 193, 194, 195, 196) against concanavalin A (ConA)-induced T lymphocyte proliferation	[72]
188*	Bipolaquinone B
189*	Bipolaquinone C
190	Bipolaquinone D
191	Bipolaquinone E
192	Bipolaquinone F
193*	Bipolaquinone G
194*	Bipolaquinone H
195*	Bipolaquinone I
196*	Bipolaquinone J
197	Bipolarinoid A	Bipolaris zeicola	Mo Mountain of East Lake, Wuhan City of Hubei Province, China	Inhibitory activity (201, 202) against concanavalin A (ConA)-induced T lymphocyte proliferation	[73]
198	Bipolarinoid B
199	Bipolarinoid C
200	Bipolarinoid D
201*	Bipolarinoid E
202*	Bipolarinoid F
203*	Aspergorakhin B	Aspergillus gorakhpurensis F07ZB1707	Mountainous region of shennongjia Forestry District, Hubei Province of China	Inhibitory effect (203*) against Protein tyrosine phosphatases including PTP1B, SHP1, and TCPTP in vitro.	[6]
204	Aspergorakhin C
205	Aspergorakhin D
206*	Encindolene D	Penicillium sp. HFF16	Rhizosphere soil of Cynanchum bungei Decne., in Mount Tai, China	Inhibit the hepatic glucose production(206, 207, 208, 209, 210*)	[74]
207*	Encindolene E
208*	Encindolene F
209*	Encindolene G
210*	Encindolene H
211*	4α-methyl-9α-methoxyandrosta-8,15-diene-3,17-dione	Curvularia borreriae strain HS-FG-237	-	Cytotoxicity; anti-inflammatory activity	[75]
212*	Unnamed	Aspergillus flavus JDW-1	-	Cytotoxicity	[76]
213*	Aspergorakhin A	Aspergillus gorakhpurensis F07ZB1707	Mountainous region of Shennongjia Forestry District, Hubei Province of China	Inhibitory effect against Protein tyrosine phosphatases including PTP1B, SHP1, and TCPTP in vitro.	[6]
Ketones
214*	1-(3,5-dihydroxyphenyl)-4-hydroxypentan-2-one	Exophiala pisciphila PHF-9	Yunnan Province, China,	Cytotoxicity	[77]
215*	Pyrenocine J	Curvularia affifinis strain HS-FG-196	Jilin Province, China	Cytotoxicity	[78]
216	Pyrenochaetic acid D	Curvularia affifinis strain HS-FG-196	Jilin Province, China	Cytotoxicity	[78]
217*	Euparvione	Eupenicillium parvum	Cuba	Binding human µ–opioid receptors	[79]
218	Euparvilactone	Eupenicillium parvum	Cuba	Binding human µ–opioid receptors	[79]
219	Penicillither	Penicillium sp. PSU-RSPG99	Surat Thani Province, Thailand	-	[80]
220–221, 222, 223	Tanzawaic acids I-L	Penicillium sp. IBWF104-06	Kaiserslautern, Germany	Inhibited the conidial germination in Magnaporthe oryzae	[81]
224–226	Blennolides H-J	Alternaria sp.	Vicinity of Wailua Falls, Hawaii	-	[82]
227–230	Pyrenochaetic acids E-H	Alternaria sp.	Vicinity of Wailua Falls, Hawaii	-	[82]
231*, 232,233	Asperochrins A-C	Aspergillus ochraceus MA-15	Hainan Province, China	Antibacterial activity	[83]
234*	Iizukine A	Aspergillus iizukae	Shandong Province, China	Cytotoxicity against cancer cell	[84]
235–236	Penicipyrans A-B	Penicillium raistrickii	Shandong Province, China	Cytotoxicity	[85]
237*	Penicipyran E	Penicillium raistrickii	Shandong Province, China	Cytotoxicity	[85]
238*, 239	Penijanthinones A-B	Penicillium janthinellum HK1-6	Hainan Province, China	Displayed potent antibacterial activity	[86]
240, 241	Talaroketals A-B	Talaromyces stipitatus ATCC 10500	-	Antibacterial activity	[87]
242	Aspergorakhin E	Aspergillus gorakhpurensis F07ZB1707	Mountainous region of Shennongjia Forestry District, Hubei Province of China	-	[6]
243	Aspergorakhin F
244	Aspergorakhin G
245	Aspergorakhin H
246	Aspergorakhin I
247	Aspergorakhin J
248	Aspergorakhin L
249	Talaromycesone C	Talaromyces macrosporus KKU-1NK8	Khon Kaen Province, Thailand	Antimalarial activity (251); Cytotoxicity (250, 251, 253)	[88]
250, 251, 252, 253*, 254	Macrosporusones A-E	Talaromyces macrosporus KKU-1NK8	Khon Kaen Province, Thailand		[88]
255, 256	Bacillisporins I-J	Talaromyces bacillisporus BCC17645	Khao Yai National Park, Nakhon Ratchasima Province, Thailand	Cytotoxicity (255-258); Antibacterial activity (257*)	[89]
257, 258	Duclauxamides B-C	Talaromyces bacillisporus BCC17645		Cytotoxicity (255-258); Antibacterial activity (257*)	[89]
259	9a-epi-Bacillisporin E	Talaromyces stipitatus	-	Antimicrobial activity; Cytotoxicity	[90]
260	Bacillisporin F
261	1-epi-bacillisporin F
262, 263*	Bacillisporins G-H
264	Aspergone	Aspergillus sp. SCSIO41002	Hainan Province, China	-	[91]
265*	7-methoxy-2,2-dimethyl-4-octa-4’,6’-dienyl-2H-napthalene-1-one	Penicillium sp	Punjab, India	Antimicrobial activity; Cytotoxicity	[92]
266–268	Aspereusins C-E	Aspergillus terreus YIM PH30711	New Delhi, India	-	[93]
269	Penicillixanthone	Penicillium sp. PSU-RSPG99	Surat Thani Province, Thailand		[80]
270*	Castochrin	Alternaria sp.	Vicinity of Wailua Falls, Hawaii	Antibacterial activity; Cytotoxic activity	[82]
271	Blennolide G	Alternaria sp.	Vicinity of Wailua Falls, Hawaii	Antibacterial activity; Cytotoxic activity	[82]
272	Penicillone C	Penicillium citrinum PSU-RSPG95	Surat Thani Province, Thailand.	-	[94]
273*	6-[1,2-dimethyl-6-(2-methyl-allyloxy)-hexyl]-3-(2-methoxy-phenyl)-chromen-4-one	Penicillium sp. HT-28	Punjab, India	Antibacterial activity	[95]
274	2-(2’,4’,6’-Trihydroxyphenyl)-(7-hydroxy-5-methyl) chromone	Aspergillus aculeatus	Chongqing, China	-	[96]
275	Penicillanthone	Penicillium aculeatum PSU-RSPG105	Surat Thani Province, Thailand	-	[97]
276, 277	Oxisterigmatocystins E-F	Botryotrichum piluliferum	Sangkhla Buri, Kanchanaburi Province, Thailand	Antimalarial activity (276); Cytotoxicity(276, 277*)	[98]
278*, 279	Penixanthones A-B	Penicillium sp. SYFz-1	Hainan Province, China	Cytotoxicity	[99]
280*	Methyl-(2-chloro-l,6-dihydroxy-3-methylxanthone)-8-carboxylate	Aspergillus iizukae	Shandong Province, China	Antiviral activity	[100]
281*	Methyl-(4-chloro-l,6-dihydroxy-3-methylxanthone)-8-carboxylate
282	Methyl-(4-chloro-6-hydroxy-1-methoxy-3-methylxanthone)-8-carboxylate
283	Methyl-(6-hydroxy-1-methoxy-3-methylxanthone)-8-carboxylate
284	4-chloro-1,6-dihydroxy-3-methylxanthone-8-carboxylic acid
285*,286–287	Blennolides L-N	Trichoderma asperellum PSU-PSF14	Narathiwat Province, Thailand	Antifungal activity	[101]
288	Wentixanthone A	Aspergillus wentii	Hypersaline lake El Hamra in Wadi El-Natrun, Egypt	-	[102]
289–290	Fusarpyrones A-B	Fusarium solani PSU-RSPG37	Suratthani Province, Thailand	-	[103]
291–292	Coniochaetones E-F	Penicillium citrinum PSU-RSPG95	Surat Thani Province, Thailand	-	[94]
293	Penicillanone	Penicillium citrinum PSU-RSPG95	Surat Thani Province, Thailand	-	[94]
294*	8’-O-(3R-Hydroxy-butyryl)-rasfonin	Cephalotrichum microsporum (SYP-F 7763)	Yunnan Province, China	Antibacterial (295-297) activity; Anti-tumor activity (294, 295)	[104]
295-297	Cemironins A-C
298	4-Methyl-8,10-dihydroxy-caprylic acid
299	Chevalone F	Neosartorya pseudofischeri	Chiang Mai forest, Thailand	Antibacterial activity	[40]
300*	11-hydroxychevalone E	Neosartorya pseudofischeri	Chiang Mai forest, Thailand	Antibacterial activity	[40]
301, 302, 303*	Peninaphones A-C	Penicillium sp. HK1-22	Hainan Province, China	Antibacterial activity (301, 302); Antimicrobial activity (303*)	[105]
304	Helvafuranone	Aspergillus nidulans BF0142	Hokkaido, Japan	-	[106]
305*	(±)-europhenol A	Eurotium rubrum MA-150	Andaman Sea coastline, Thailand	DPPH radical scavenging activities	[107]
306	Aspersclerotiorone E	Aspergillus sclerotiorum PSU-RSPG178	Surat Thani Province, Thailand	-	[108]
307*	Harzianone	Cephalotrichum microsporum	Yunnan Province, China	Antibacterial activity	[109]
308*	Harzianol
309*	Harzianol acid
310	Gotjawaside	Auxarthron sp. KCB15F070	Volcanic island Jeju, Korea	-	[110]
311	Gotjawalide	Auxarthron sp. KCB15F070	Volcanic island Jeju, Korea	-	[110]
312, 313	Thiocarboxylics A-B	Penicillium sp. sb62	Hunan Province, China	Antibacterial activity	[111]
314, 315	Thiocarboxylics C_1-2
316, 317	Thiocarboxylics D_1-2
318, 319	GregatinsF_1-2
320, 321	Gregatins G_1-2
322	R-Hexitronic acid	Penicillium sp. FG9RK	Agulu in Anambra state, Nigeria	-	[112]
323, 324, 325*	Peneciraistins A-C	Penicillium raistrickii	Shandong Province, China	Radical scavenging activity against DPPH (323, 324); Induces caspase-independent autophagic cell death through mitochondrial-derived reactive oxygen species production in lung cancer cells (325*)	[11,166]
326*	Sporulosol	Paraconiothyrium sporulosum	Jiangxi Province, China	Cytotoxicity	[113]
327	(+)-(5S)-arugosin K	Talaromyces flavus	Sinkiang Province, China	-	[114]
328	(-)-(5R)-arugosin K
329	(+)-(5S)-arugosin L
330	(-)-(5R)-arugosin L
331	(+)-(5S)-arugosin M
332	(-)-(5R)-arugosin M
333	Arugosin N
334–335	Asperunguisones A-B	Aspergillus unguis PSU-RSPG204	Surat Thani Province, Thailand	-	[115]
336	(±)-4-hydroxy-3-methoxy-5-methyl-2-cyclopentenone	Aspergillus Sclerotiorum	Shandong Province, China	-	[116]
337*	Polluxochrin	Alternaria sp.	Vicinity of Wailua Falls, Hawaii	Antibacterial activity; Cytotoxic activity	[82]
338*	Dioschrin
339	Dimethylamide asterrate
340*, 341–342	Nectriatones A-C	Nectria sp. B-13	Arctic island of Spitzbergen, Svalbard	Cytotoxicity	[117]
343	Curvulopyran	Aspergillus polyporicola PSU-RSPG187	Surat Thani Province, Thailand	-	[118]
344	ent-curvulone A	Aspergillus polyporicola PSU-RSPG187	Surat Thani Province, Thailand	-	[118]
345	7-methoxy-2,3,6-trimethylchromone	Exophiala pisciphila PHF-9	Yunnan Province, China	-	[77]
346, 347	Penicilones G-H	Penicillium janthinellum HK1-6	Hainan Province, China	Show moderate inhibitory activity against Gram-positive bacteria (346); Antibacterial activity (347)	[86]
348	Tetrahydrotrichodimer ether	Clonostachys rosea YRS-06	Gansu Province, China	Antibacterial activity	[119]
349, 350	Dihydrotrichodimer ethers A-B	Clonostachys rosea YRS-06	Gansu Province, China	Antibacterial activity	[119]
351*	Isochaetomium A₂	Chaetomium microcephalum	Sichuan Province, China	Antibacterial activity; Inhibitory effects on mouse spleen cell proliferation	[120]
352	Wentiphenone A	Aspergillus wentii	Hypersaline lake El Hamra in Wadi El-Natrun, Egypt	-	[102]
353, 354, 355, 356*	Penicilones A-D	Penicillium janthinellum HK1-6	Hainan Province, China	Antibacterial activity	[121]
357, 358, 359–362	Talaraculones A-F	Talaromyces aculeatus	Shandong Province, China	Inhibitory activity against α-glucosidase (357, 358); Antibacterial activity (358*)	[122]
363*	Isoasteltoxin	Aspergillus ochraceopetaliformis SCSIO 05702	Chinese Antarctic station	Antiviral activity	[53]
364*	Curvularone A	Curvularia inaequalis strain HS-FG-257	Heilongjiang Province, China	Antitumor activity	[123]
365*	4-hydroxyradianthin	Curvularia inaequalis strain HS-FG-257	Heilongjiang Province, China	Antitumor activity	[123]
366	1-(2’,4’-dihydroxy-5’-methyl-3’-methylsulfanylmethylphenyl)-ethanone	Penicillium crustosum YN-HT-15	Yunnan Province, China	-	[124]
367*	(E)-4-Hydroxy-3-[(4-hydroxy-3-methylbut-2-en-1-yl)oxy] benzoic acid	Aspergillus aculeatus	Chongqing, China	Antagonism to DPPH	[96]
368–369	Talaflavuols B-C	Talaromyces flavus BYD07-13	Guangzhou Province, China	-	[125]
370	Aspereusin B	Aspergillus terreus YIM PH30711	New Delhi, India	-	[93]
371*	Seltsamiayu	Seltsamia galinsogisoli sp. nov.	Liaoning Province, China	Antibacterial activity	[126]
372*	Galinsogisoliyu	Seltsamia galinsogisoli sp. nov.	Liaoning Province, China	Antibacterial activity	[126]
373*	1-(4-hydroxy-2,6-dimethoxy-3,5-dimethylphenyl)-2-methyl-1-butanone	Aspergillus sp.	Riyadh, Saudi Arabia	Antimicrobial activity	[127]
374	Dictyosporin D	Dictyosporium digitatum	Herod, Illinois, USA	-	[56]
375	Dictyophthalide A
376–379	Dictyofurans A-D
380	Dictyosporone A
381–382	Xylariolides E-F
383*	Aspergorakhin K	Aspergillus gorakhpurensis F07ZB1707	Mountainous region of Shennongjia Forestry District, Hubei Province of China	inhibitory effect against Protein tyrosine phosphatases including PTP1B, SHP1, and TCPTP in vitro.	[6]
384	Sulfurasperine A	Aspergillus fumigatus GZWMJZ-152	Caves in Guizhou province of China	Antioxidant capacity (385, 387);protective effects (385, 386) on oxidative injury of PC12 cells induced by H2O2	[128]
385*	Sulfurasperine B ((±)-2)
386*	Sulfurasperine C ((±)-3)
387*	Sulfurasperine D
Phenylpropanoids
388, 389, 390*, 391–393	Spiromastols A-F	Spiromastix sp. MCCC 3A00308	South Atlantic Ocean	Antibacterial activity	[129]
394, 395	Spiromastols J-K	Spiromastix sp. MCCC 3A00308	South Atlantic Ocean	Antibacterial activity	[129]
396, 397, 398*	Myrochromanols A-C	Myrothecium verrucaria HL-P-1	Heilongjiang Province, China	Inhibited lipopolysaccharide (LPS)-induced NO production in BV2 cells	[130]
399*	Peneciraistin D	Penicillium raistrickii	Shandong Province, China	Radical scavenging activity against DPPH	[11]
400, 401	Talacoumarins A-B	Talaromyces flavus BYD07-13	Hebei Province, China	Anti-Aβ₄₂ aggregation activity	[131]]
402–403, 404*	Spiromastols G-I	Spiromastix sp. MCCC 3A00308	South Atlantic Ocean	Antibacterial activity	[129]
405*	(3S)-6-O-(4’-O-methyl-6’-acetyl-β-D-glucopyranoside)-7-O-methyl-8-hydroxyl-3-[(3E)-penta-3-enyl]-3,4-dihydroisocoumarin	Metarhizium anisopliae DTH12-10	-	Antibacterial activity	[132]
406	(3S)-7-O-(4’-O-methyl-β-D-glucopyranoside)-6,8-dihydroxyl-3-[(3E)-pent-3-enyl]-3,4-dihydroisocoumarin
407	(3S)-6-O-(4’-O-methyl-β-D-glucopyranoside)-7-O-methyl-8-hydroxyl-3-[(3E)-pent-3-enyl]-3,4-dihydroisocoumarin
408	(3S)-6-O-(4’-O-methyl-β-D-glucopyranoside)-8-hydroxyl-3-[(3E)-pent-3-enyl]-3,4-dihydroisocoumarin
409	(3S)-6-O-(4’-O-methyl-β-D-glucopyranoside)-5,8-dihydroxyl-3-[(3E)-pent-3-enyl]-3,4-dihydroisocoumarin
410	6-O-(4’-O-methyl-β-D-glucopyranoside)-7-O-methyl-8-hydroxyl-3-[(3E)-penta-3-enyl]-isocoumarin
411	(3R)-6-O-(4’-O-methyl-β-D-glucopyranoside)-8-hydroxyl-3-[(1E,3E)-penta-1,3-dienyl]-dihydroisocoumarin
412	(3R)-6-O-(4’-O-methyl-β-D-glucopyranoside)-7-O-methyl-8-hydroxyl-3-[(1E,3E)-penta-1,3-dienyl]-dihydroisocoumarin
413–414	Talaisocoumarins A-B	Talaromyces flavus BYD07-13	Guangzhou Province, China	-	[125]
415	Talaflavuol A	Talaromyces flavus BYD07-13	Guangzhou Province, China	-	[125]
416–417	Penicipyrans C-D	Penicillium raistrickii	Shandong Province, China	-	[85]
418	(3R,4R)-4,8-Dihydroxy-5-(hydroxymethyl)-3-methylisochroman-1-one	Hypoxylon sp.	Heilongjiang Province, China	-	[133]
419	(3R,4S)-4,8-Dihydroxy-5-(hydroxymethyl)-3-methylisochroman-1-one	Hypoxylon sp.	Heilongjiang Province, China	-	[133]
420*	(9R*)-8-methyl-9,11-dichlorodiaporthin	Hamigera fusca NRRL 35721	Maoueni, Grande Comore Island	Cytotoxic activity against cancer cell lines	[134]
421*	(9S*)-8-methyl-9,11-dichlorodiaporthin	Hamigera fusca NRRL 35721	Maoueni, Grande Comore Island	Cytotoxic activity against cancer cell lines	[134]
422*	Exophiarin	Exophiala sp.	Kaziranga National Park, Assam	Improvement in glucose uptake activity when tested in rat skeletal muscle cell line L6	[135]
Quinones
423*, 424	Citriquinones A-B	Penicillium citrinum	University of SriJayewardenepura, Sri Lanka	Antibacterial activity; Cell migration inhibitory activity	[136]
425	Penicilliquinone	Penicillium sp. PSU-RSPG99	Surat Thani Province, Thailand	-	[80]
426	Peniciherqueinone	Penicillium herquei PSU-RSPG93	Surat Thani Province, Thailand	-	[137]
427*, 428	Aspergillussanones A-B	Aspergillus sp. PSU-RSPG185	Surat Thani Province, Thailand	Cytotoxicity	[30]
429*	Solaninaphthoquione	Fusarium solani PSU-RSPG227	Surat Thani Province, Thailand	Cytotoxic; Antimalarial activity	[138]
430	Kumbicin D	Aspergillus kumbius FRR6049	Queensland, Australia	-	[22]
431*	PA3-d10	Aspergillus flavus	Iran	Antimicrobial activity	[139]
432–433	Wentibianthrones A-B	Aspergillus wentii	Hypersaline lake El Hamra in Wadi El-Natrun, Egypt	-	[102]
434	Wentibianthrone C (cis/trans)	Aspergillus wentii	Hypersaline lake El Hamra in Wadi El-Natrun, Egypt	-	[102]
435	Herqueilenone A	Penicillium herquei FT729	Active volcano, Hawaii	-	[140]
436*	ent-12-methoxyisoherqueinone	Penicillium herquei FT729	Big Island, Hawaii.	Inhibitory activity (436*) against indoleamine 2.3-dioxygenase 1 (IDO1)	[141]
437	(−)-scleroamide
438	(+)-scleroamide
Esters and lactones
439	3-Hydroxy-5-methylphenyl 2.4-dihydroxy-6-methylbenzoate	Neosartorya pseudofischeri	Angthong Province, Thailand	-	[10]
440–443, 444, 445	Talapolyesters A-F	Talaromyces flavus BYD07-13	Hebei Province, China	Cytotoxic activity	[142]
446	R-3-(3’-acetyl-2’,6’-dihydroxy-5’-methylphenyl)-2-methyl-propionic acid methyl ester	Penicillium crustosum YN-HT-15	Yunnan Province, China	-	[124]
447	4-(4-Hydroxyphenethoxy)-4-oxobutanoic acid	Fusarium solani PSU-RSPG227	Surat Thani Province, Thailand	-	[138]
448–449	Penicillithiophenols A-B	Penicillium copticola PSU-RSPG138	Surat Thani Province, Thailand	-	[51]
450*	Isoaspulvinone E	Aspergillus terreus Gwq-48	Fujian Province, China	Anti-influenza A viral (H1N1)	[143]
451	Aspergillulactone	Aspergillus sp. PSU-RSPG185	Surat Thani Province, Thailand	-	[30]
452, 453	Cinatrins D-E	Virgaria boninensis FKI-4958	Bonin Islands, Tokyo, Japan	Antibacterial activity	[44]
454	Asperlide	Aspergillus unguis PSU-RSPG199	Surat Thani Province, Thailand	-	[144]
455	Aspersidone	Aspergillus unguis PSU-RSPG199	Surat Thani Province, Thailand	-	[144]
456, 457, 458, 459*, 460, 461	Penicimenolides A-F	Penicillium sp. SYP-F-7919	Yunnan Province, China	Cytotoxicity; Inhibitory effect on NO production	[145]
462–465	Aspersclerotiorones A-D	Aspergillus sclerotiorum PSU-RSPG178	Surat Thani Province, Thailand	-	[108]
466–467	Aspersclerotiorones F-G	Aspergillus sclerotiorum PSU-RSPG178	Surat Thani Province, Thailand	-	[108]
468*	eut-Guaiane sesquiterpene	Eutypella sp. D-1	London Island of Kongsfjorden, Arctic	Antibacterial activity; Cytotoxicity	[146]
469, 470	Pochoniolides A-B	Pochonia chlamydosporia var. spinulospora FKI-7537	Niijima, Tokyo, Japan	Antioxidant activity	[147]
471, 472, 473*	Aspersclerolides A-C	Aspergillus Sclerotiorum	Shangdong Province, China	Cytotoxic activity (471, 473); Antibacterial activity (472, 473)	[116]
474	(±)-Aspersclerolide D	Aspergillus Sclerotiorum	Shangdong Province, China		[116]
475–476	Botryosphaerilactones D-E	Lasiodiplodia theobromae NSTRU-PN1.4	Nakhon Si Thammarat Province, Thailand	-	[148]
477	Therlanubutanolide A	Thermomyces lanuginosus	Yunnan Province, China	-	[149]
478*	6-ethoxy-5,6-dihydropenillic acid	Penicillium sp. BF-0343	Fuji Cemetery, Shizuoka, Japan	Inhibited BMP-induced ALP activity	[150]
479	Ilyoresorcy A	Ilyonectria sp. sb65	Hunan Province, China	Inhibition of ConA-induced T-cell proliferation (481, 482); Immunosuppressive effects toward the LPS-induced B-cell proliferation (484, 485, 488*)	[151]
480*	Atrop-ilyoresorcy A
481, 482, 483, 484, 485, 486, 487, 488–490	Ilyoresorcys B-K
Other compounds
491*, 492–493	Prenylterphenyllins A-C	Aspergillus taichungensis ZHN-7-07	-	Cytotoxicity	[152]
494*	4”-dehydro-3-hydroxyterphenyllin
495, 496*, 497	Prenylcandidusins A-C
498	4-hydroxy-3-(3-methyoxy-3-methylbutyl)-benzoic acid	Curvularia inaequalis strain.HS-FG-257	Heilongjiang Province, China	-	[153]
499	(Z)-2-(5-hydroxyhexyl)pent-2-enedioic acid	Gongronella butleri	Forest at Koukoue, Cameroon	-	[154]
500	(Z)-2-hexylpent-2-enedioic acid
501	(Z)-2-(5-oxohexyl)pent-2-enedioic acid
502	(Z)-oct-2-ene-1,3,8-tricarboxylic acid
503	(Z)-2-(7-hydroxyoctyl)pent-2-enedioic acid
504	(Z)-2-(3-methoxy-3-oxopropylidene)decanoic acid
505	(Z)-2-(7-oxooctyl)-pent-2-enedioic acid
506	(Z)-2-(8-hydroxydecyl)pent-2-enedioic acid
507, 508, 509*	Peniciketals A-C	Penicillium raistrichii	Shangdong Province, China	Cytotoxic activity	[155]
510*	MIG0310	Fusarium brachygibbosum strain MS-R1	Mediterranean forest, Israel	Antimicrobial activity	[156]
511–512	Aspergillusols A-B	Aspergillus sp. PSU-RSPG185	Surat Thani Province, Thailand	-	[30]
513	Aspergillusic acid	Aspergillus sp. PSU-RSPG185	Surat Thani Province, Thailand	-	[30]
514	11’-carboxygymnastatin N	Gymnascella dankaliensis	Giza pyramids, Egypt	Cytotoxicity	[157]
515	Gymnastatin S
516	Dankamide
517*	Aranorosin-2-methylether
518*	Iizukine B	Aspergillus iizukae	Shandong Province, China	Cytotoxicity against cancer cell	[84]
519*	Screlotiumol	Sclerotium rolfsii	District Malakand, Khyber Pakhtunkhwa Pakistan	Effective multidrug resistant (MDR) mediated by P-glycoprotein (P-gp) modulator	[158]
520	Versicorin	Aspergillus versicolor SC0156	Guangdong Province, China	-	[159]
521–522, 523*	Unnamed	Aspergillus sclerotiorum PSU-RSPG178	Surat Thani Province, Thailand	Activity against HMG-CoA reductase	[160]
524	Asterreusin A	Aspergillus terreus YIM PH30711	New Delhi, India	Inhibitive activities against acetylcholinesterase (AChE)	[93]
525	Unnamed
526*	Aspereusin A
527	Epiaspereusin A
528–530	Penicillidic acids A-C	Penicillium aculeatum PSU-RSPG105	Surat Thani Province, Thailand	-	[97]
531–532, 533*	Aspergillusethers B-D	Aspergillus unguis PSU-RSPG204	Surat Thani Province, Thailand	Antifungal activity	[115]
534–535	Melleusins A-B	Aspergillus melleusYIM PHI001	New Delhi, India	-	[161]
536*	3-methylpentyl-2,4-dichloroasterrate	Aspergillus flavipes PJ03-11	Liaoning Province, China	Cytotoxic activity	[162]
537	6R,8R-dihydroxy-9Z,12Z-octadecadienoic acid	Penicillium javanicum HK1-22	Hainan Province, China.	-	[163]
538	Methyl-6R,8R-dihydroxy-9Z,12Z-octadecadienoate	Penicillium javanicum HK1-22	Hainan Province, China.	-	[163]
539	Penoxalin	Penicillium oxalicum GY1	Shanghai, China	Cytotoxic activity	[164]
540–541	Penisochromans A-B
542*	2,6-dihydroxy-4-[(2R)-2-hydroxyheptyl] benzoic acid
543*	Pyrenosetin D	Pyrenochaetopsis sp. FVE-087	Falckenstein Beach, Kiel Fjord, Baltic Sea, Germany	Cytotoxic activity	[165]
544	Unnamed	Aspergillus calidoustus	Dianchi Lake, Yunnan Province.China		[58]
545*	4-Methoxy-7-methylbenzo[d]thiazole-5,6-diol	Aspergillus fumigatus GZWMJZ-152	Caves in Guizhou province of China	Radical-scavenging activity (545, 546) against 2.2-diphenyl-1-picrylhydrazyl free radicals	[128]
546*	2-Hydroxymethyl-4-methoxy-7-methylbenzo[d]thiazole-5,6-diol	Aspergillus fumigatus GZWMJZ-152	Caves in Guizhou province of China		[128]

Note: *Bioactive compounds.