Table 1.

Search terms used to identify articles for review

PICO	Inclusion criteria	Search terms	Exclusion criteria
Population and	Frail, and	"frail" OR "multimorbid" OR "highly comorbid"	No assessment of frailty during the index admission
	Elderly, and	"elderly" OR "older" OR "old"	If the study includes patients aged ≤ 75 and no subgroup analysis is presented for patients aged ≥ 75, or if the mean/median age < 75
	Any ACS	"acs" OR "acute coronary" OR "myocardial infarction" OR "unstable angina" OR" "stemi" OR "nstemi" OR "nsteacs" OR "nste-acs" OR "ua"	If the study includes non-ACS patients, e.g., stable angina, and no subgroup analysis is presented for ACS subgroup
Interventions, and	Any coronary intervention strategy or reperfusion treatment (including revascularisation procedures)	"pci" OR "percutaneous coronary intervention" OR "angiogra*" OR "invasive management" OR "invasive strategy" OR "medical management" or "conservative strategy" OR "conservative management" OR "cabg" OR "coronary artery bypass" OR "thromboly*"
Comparisons, and	Pairwise comparison of outcomes between any two coronary interventions from a Randomized controlled trial (RCT), a Meta-analysis or an observational study	"treatment effect" OR "treatment benefit" OR "treatment outcomes" OR "versus" OR "vs" OR "compar*"	No comparative outcomes between treatments are presented, e.g., a methods paper Not a primary research article, e.g., a review article
Outcomes	Any health outcome. Examples include all-cause death, recurrent myocardial infarction, stroke, rehospitalization, quality of life and bleeding	No limits applied
Filters		English, from 1990 to latest