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. 2022 Aug 19;127(8):1461–1472. doi: 10.1038/s41416-022-01927-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — mRNA expression levels of α-SMA, collagen-I and IL-1β in ihPSCs (a) and hpPSCs (b) transfected with pCDH-ESE3 or pCDH-Vector plasmids. c Protein expression levels of α-SMA, collagen-I and IL-1β in ihPSCs, hpPSCs and mpPSCs transfected with pCDH-ESE3 or pCDH-Vector plasmids. mRNA expression levels of α-SMA, collagen-I and IL-1β in ihPSCs (d) and hpPSCs (e) transfected with sh-Vector or sh-ESE3 plasmids. f Protein expression levels of α-SMA, collagen-I and IL-1β in ihPSCs, hpPSCs and mpPSCs transfected with sh-Vector or sh-ESE3 plasmids. g IHC analysis of α-SMA, collagen-I and IL-1β expression levels in the mouse xenograft samples. *P < 0.05, **P < 0.01 and ***P < 0.001.