. 2022 Oct 11;12:17012. doi: 10.1038/s41598-022-21394-y

Table 2.

Top results of integrative enrichment analysis with IPA.

Diseases or functions annotation	p-value	Activation z-score	Metabolites	Proteins	Phospho-proteins
Abnormality of cerebral cortex	8.3E−5	− 1.951	Glutamate*	CD81, CELSR3, CYGB, F12, TNR*	VIM*
Apoptosis	6.1E−5	− 1.458	O-acetyl carnitine, alpha-tocopherol, choline, ethanolamine, glycine, glutamate, glutamine, ethanolamine phosphate, S-adenosylmethionine	B2M, CYGB, GHRH, HAPLN1, IFIT3, ISG15, MTSS1, PCP4*, SERPINB9, SPP1, STAR, VCAN	ADAM10, EIF4B, HNRNPC, MAP2K4, PPP1R2, SPP1, UBE2V2, VIM*, ZFP36L1
Synthesis of protein	1.9E−7	− 1.315	Creatine, glycine, aspartate, glutamate	IGFBP2, ISG15, SPP1	EEF2, EIF4B, LARP1, MAP2K4, PPP1R2, SPP1, VIM*, ZFP36L1
Metabolism of protein	7.9E−08	− 0.781	Creatine, glycine, aspartate, glutamate	B2M, CD81, F12, F9, IGFBP2, ISG15, SPP1, VCAN	ADAM10, EEF2, EIF4B, LARP1, LONP1, MAP2K4, PPP1R2, SPP1, VIM*, ZFP36L1
Synthesis of amino acids	4.4E−5	− 0.555	Creatine, glycine, aspartate, glutamate	VCAN
Transmembrane potential of mitochondria	7.4E−5	0.958	Glutamate, S-adenosylmethionine	B2M, STAR	LONP1, MAP2K4, VIM
Conversion of lipid	2.0E−7	1.476	O-acetyl carnitine, alpha-tocopherol, creatine, glycine, guanidoacetic acid, glutamate, glutamine, S-adenosylmethionine	CYGB, STAR
Peroxidation of lipid	2.6E−08	1.82	O-acetyl carnitine, alpha-tocopherol, creatine, glycine, guanidoacetic acid, glutamate, glutamine, S-adenosylmethionine	CYGB
Uptake of amino acids	6.5E−6	2.173	Choline, glycine, guanidoacetic acid, aspartate, glutamate	TNR*
Progressive neurological disorder	6.0E−6	2.186	O-acetyl carnitine, choline, creatine, glutamate, N-acetylaspartic acid, S-adenosylmethionine, glycerophosphocholine	CHCHD2, F12, IGFBP2, ISG15, SPP1, STAR, TNR*	ADAM10, EEF2, SPP1, VIM, ZFP36L1

*Indicates molecules with |log2(ratio)|> 1.5.