Table 2.

Estimated demand on colonoscopy (positive FIT), screening benefits including screen-detected and screen-prevented CRC, interval cancers prevented, adenomas and AA detected and deaths prevented per 100,000 screened in a 15-year period, by f-Hb thresholds (μg/g) and interscreening intervals (years).

Threshold	Interscreening interval	Colonoscopy demand	Screen-detected CRC	Screen-prevented CRC	AA detected	Adenomas detected	IC prevented	Deaths prevented*
20	1	108,131	1317	658	11,830	25,006	91	503
	2	58,812	1216	550	9671	20,894	137	427
	3	37,391	1130	429	7720	16,315	146	345
	4	30,151	1060	383	7185	14,550	160	311
	5	22,877	958	313	6120	11,889	150	260
40	1	72,864	1385	528	10,373	20,066	82	424
	2	39,595	1246	408	7944	15,488	113	339
	3	25,112	1118	302	6098	11,472	113	263
	4	20,219	1028	261	5523	9935	118	232
	5	15,295	904	208	4577	7912	108	190
80	1	41,254	1432	374	7992	14,222	74	329
	2	22,448	1212	260	5594	9887	89	242
	3	14,254	1019	182	4060	6902	81	180
	4	11,491	906	153	3542	5800	81	154
	5	8710	762	119	2835	4507	70	124
120†	1	29,431	1432	286	6451	10,857	70	272
	2	16,092	1142	186	4259	7086	76	191
	3	10,283	909	126	2986	4796	65	138
	4	8327	784	105	2549	3972	62	116
	5	6360	635	80	2003	3053	53	91
150	1	24,642	1437	243	5591	9249	64	246
	2	13,495	1119	154	3590	5857	66	169
	3	8644	871	103	2476	3911	56	121
	4	7013	743	85	2091	3219	53	101
	5	5373	592	65	1629	2463	44	79
180	1	21,021	1427	211	5071	8015	62	224
	2	11,500	1077	131	3184	4961	61	151
	3	7360	816	86	2170	3281	50	106
	4	5968	686	71	1821	2688	46	88
	5	4570	537	658	1412	2050	38	68

FIT faecal immunochemical test, CRC colorectal cancer, AA advanced adenomas, IC interval cancer, f-Hb faecal haemoglobin concentration.

^†Estimates for the current screening policy are in bold.

*Deaths prevented for 5 years following diagnosis.