Table 4.

Univariate and multivariate analysis for risk factors of overall survival

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Generation (4 and 3 vs 2)	1.377 (0.668 to 2.836)	0.386
Mutation (truncating mutation vs missense mutation)	1.829 (1.096 to 3.052)	0.021	1.435 (0.815 to 2.526)	0.211
Classification (VHL type 2 vs VHL type 1)	0.253 (0.079 to 0.807)	0.020	0.420 (0.126 to 1.402)	0.159
Sex (female vs male)	0.881 (0.526 to 1.477)	0.632
Mutation region		0.550
Exon 2 vs exon 1	1.052 (0.499 to 2.217)
Exon 3 vs exon 1	0.654 (0.319 to 1.341)
Other vs exon 1	1.185 (0.603 to 2.327)
Onset age (≤28 vs >28)	1.821 (1.051 to 3.154)	0.033	1.490 (0.831 to 2.671)	0.181
First symptom (haemangioblastoma vs abdomen)	2.908 (1.495 to 5.653)	0.002	2.273 (1.142 to 4.524)	0.019

Significant p values (p<0.05) are bolded.

VHL, von Hippel-Lindau.