Table 2.

Changes in IBS-SSS, quality of life, anxiety, depression and somatic symptoms (PHQ15) after 8, 16 and 24 weeks of treatment

Changes after 8 weeks of treatment
	Medication (n=231)	Diet (n=222)	P value*	P value†
IBS-SSS, mean±SD	−76.91±7.42	−97.42±7.37	0.02	0.05
IBS-QoL, mean±SD	−7.36±12.45	−8.07±11.45	0.48	0.59
Anxiety, mean±SD	−0.97±0.19	−1.21±0.18	0.22	0.32
Depression, mean±SD	−1.08±0.27	−1.39±0.26	0.17	0.39
Somatisation, mean±SD	−1.26±0.23	−1.82±0.23	0.09	0.09
Changes after 16 weeks of treatment
	Medication (n=206)	Diet (n=203)	P value*	P value†
IBS-SSS, mean±SD	−78.50±8.04	−104.98±7.66	0.005	0.02
IBS-QoL, mean±SD	−8.69±14.07	−9.35±12.23	0.29	0.62
Anxiety, mean±SD	−1.03±0.20	−1.31±0.18	0.22	0.30
Depression, mean±SD	−1.19±0.28	−1.63±0.25	0.25	0.23
PHQ15, mean±SD	−1.48±0.24	−1.81±0.22	0.70	0.33
Changes after 24 weeks of treatment
	Medication (n=192)	Diet (n=196)	P value*	P value†
IBS-SSS, mean±SD	−86.64±7.81	−97.12±8.18	0.12	0.35
IBS-QoL, mean±SD	−9.60±14.32	−10.49±12.79	0.27	0.63
Anxiety, mean±SD	−1.16±0.21	−1.33±0.19	0.19	0.53
Depression, mean±SD	−1.13±0.30	−1.45±0.28	0.22	0.43
PHQ15, mean±SD	−1.90±0.29	−1.84±0.24	0.96	0.91

*Based on completers and Mann-Whitney test.

†Based on all available data and mixed models.

IBS-QoL, IBS quality of life; IBS-SSS, IBS Symptom Severity Scale.