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. 2022 Oct 10;15:25168657221126314. doi: 10.1177/25168657221126314

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Quantile-quantile plot of epigenome-wide associations with self-reported stress for mothers. Associations of DNAm level at each CpG site with total stress score was tested using linear mixed model adjusted for age, smoking, cell-type proportions and top 10 principal components. The total sample size is n = 228, and the overall inflation factor is 0.983 showing well-controlled type I error rate. Observed -log10(p) (y-axis) was plotted against expected -log10(p) derived from a uniform distribution (x-axis). Red straight line is y = x and the red curved lines indicate the 95% confidence interval for the expected −log10(p).