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Suggested mechanism of HIF1A-induced cardioprotection during myocardial ischemia and reperfusion injury. During myocardial ischemia and reperfusion injury, neutrophils undergo hypoxia, leading to stabilization of HIF1A. HIF1A subsequently induces increased expression and release of neuronal guidance proteins Netrin-1 by PMN. Netrin-1 then reduces a reduction in infarct sizes.
