Fig. 1.

String depiction of RAGE-ligand interactions. For clarity, only the most prominent and well-studied protein interactions are shown; AGER (RAGE), S100 family of Ca²⁺-binding molecules –S100A4, S100A6, S100A12, S100A13, S100B, S100P; TLR2, TLR, MyD88, IRAK1, TIRAP, LY96 and CD14 parts of the innate immune response pathways; ITGAM, ITGB2, ICAM1, ITGAL and ITGAX—involved in the adaptive immune response, participate in antigen presentation, leukocyte migration, and T cell cytotoxicity.

Source: https://string-db.org/ [134]