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. 2022 Sep 28;9:1021909. doi: 10.3389/fcvm.2022.1021909

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Copyright © 2022 Boovarahan, AlAsmari, Ali, Khan and Kurian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Targeting DNA methylation during I/R reduced the apoptosis and inflammation in the myocardium and blood. The methylation impact of I/R on apoptosis and inflammation was assessed from (A) mRNA expression changes in the apoptosis genes in the heart; (B) Blood mRNA expression changes in the apoptosis genes; (C) Myocardial Caspase 3 activity; (D) Blood caspase 3 activity; The representative TUNEL stained images of the groups (E) normal; (F) I/R; (G) Di-C; (H) Di-I/R were obtained at 20× magnification and the scale bars indicate 100 μM. (I) Represents the apoptotic positive cells (TUNEL) percentage. Panel (J) represents the mRNA expression changes in inflammation genes in the myocardium and (K) represents the mRNA expression changes of inflammation genes in the blood. The graph represents the mean ± SD. The changes in gene expression are represented as fold changes from the normal group. *p < 0.05 vs. I/R.