Table 3.
List of relevant soluble immune factors according to stage and evolution disease.
| Comparison | Protein | UniProt ID | Target | Statistical analysis |
|---|---|---|---|---|
| MBLhi vs. CLL | sCD47/sIAP | Q08722 | Immune Checkpoint LT | mRMR/conventional statistics/limma-package |
| sCD27 | P26842 | Immune Checkpoint LT | mRMR/conventional statistics/limma-package | |
| TIMD-4 | Q96H15 | Immune Checkpoint LT | mRMR/conventional statistics/- | |
| sIL-2R | P31785 | Soluble receptor | mRMR/conventional statistics/limma-package | |
| sULBP1 | Q9BZM6 | Immune Checkpoint NK | mRMR/-/limma-package | |
| MBLhi vs. c-CLL vs. p-CLL | sCD48/sBLAST-1 | P09326 | Immune Checkpoint LT | mRMR/-/- |
| sCD27 | P26842 | Immune Checkpoint LT | -/conventional statistics/- | |
| sArginase-1 | P05089 | Immune Checkpoint NK | mRMR/-/- | |
| sLAG-3 | P18627 | Immune Checkpoint LT | mRMR/conventional statistics/- | |
| IL-4 | P05112 | Cytokine | mRMR/conventional statistics/limma-package | |
| sIL-2R | P31785 | Soluble receptor | -/conventional statistics/limma-package | |
| MBLhi vs. C-CLL vs. CLL-PFT vs. CLL-TFT | sIL-2R | P31785 | Soluble receptor | mRMR/conventional statistics/limma-package |
| sTIMD-4 | Q96H15 | Immune Checkpoint LT | mRMR/conventional statistics/- | |
| sSiglec-9 | Q9Y336 | Immune Checkpoint NK | mRMR/-/limma-package | |
| INF-γ | P01579 | Cytokine | mRMR/conventional statistics/- | |
| sPD-L1 | Q9NZQ7 | Immune Checkpoint LT | mRMR/-/limma-package | |
| sCD48/sBLAST-1 | P09326 | Immune Checkpoint LT | mRMR/-/- | |
| sLAG-3 | P18627 | Immune Checkpoint LT | mRMR/conventional statistics/limma-package | |
| Mutated IGHV vs. Unmutated IGHV | CXCL10/IP-10 | P02778 | Chemokine | -/conventional statistics/- |
| sCD134/sOX40 | P23510 | Immune Checkpoint LT | mRMR/-/- | |
| sULBP1 | Q9BZM6 | Immune Checkpoint NK | mRMR/-/- | |
| sLAG-3 | P18627 | Immune Checkpoint LT | mRMR/conventional statistics/- |
mRMR, maximum relevance minimum redundancy.