FIGURE 5.

Anti‐PIEZO1‐MMAE shows a strong antitumor effect in vivo without obvious side effects. (A) Tumor growth curve of TE‐1 tumor xenograft. Drug treatment started when the tumor volume reached 300 mm³. Mice were treated with Anti‐PIEZO1‐MMAE (5 mg/kg), IgG‐MMAE (5 mg/kg), and PBS, respectively; each mouse was treated every 3 days for in total of four times. n = 5 per group; (B) Body weight data of TE‐1 tumor xenograft mice with different treatments; (C) Proliferation evaluation of xenograft tumor cells with Ki‐67 staining (magnification: 200×, scale bar: 100 μm); (D) Histopathological examination of various organs including the heart, liver, spleen, lung, kidney, skin, intestine, and stomach (magnification: 100×, scale bar: 200 μm)