TABLE 4.

Mean values and precision and bias errors of gentamicin minimal PBPK model developed.

	Preterm			Term
	C 2 h (mg/L)	C 24 h (mg/L)	CL (L/h)	C 2 h (mg/L)	C 24 h (mg/L)	CL (L/h)
Mean value observed	17.7	2.92	0.09	13.8	1.41	0.19
Mean value predicted	17.4	2.62	0.11	15.4	0.89	0.23
Mpe (%)	8.08	−5.04	26.5	16.3	−28.8	27.7
Afe	1.02	0.92	1.24	1.14	0.68	1.26
Aafe	1.22	1.23	1.26	1.20	1.47	1.29

C, concentration; CL, clearance; MPE, mean prediction error; AFE, average-fold error; AAFE, absolute average-fold error.