TABLE 5.
Probability of target attainment (PTA) for efficacy and toxicity criteria (%) (MIC = 1 mg/L).
| PK/PD criterion | Preterm | Term | ||
|---|---|---|---|---|
| Conventional Reg. (q24h) | Extended interval (q48h) | Conventional Reg. (q24h) | Extended interval (q36h) | |
| Efficacy | ||||
| Cmax/MIC ≥8 | 10.8 | 99.9 | 32.3 | 99.8 |
| T>MIC ≥60% | 87.9 | 70.7 | 61.2 | 54.9 |
| Toxicity | ||||
| Cmin ≥2 mg/L | 5.0 | 5.9 | 0.4 | 1.8 |
| Cmax ≥25 mg/L | 0.0 | 6.9 | 0.0 | 6.5 |
Cmin, trough concentrations; Cmax, peak concentrations; MIC, minimum inhibitory concentration; PK/PD, pharmacokinetic-pharmacodynamic; T>MIC, percentage of time of the interval the drug concentration remains above the MIC.