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. 2022 Sep 28;13:950602. doi: 10.3389/fpsyt.2022.950602

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Copyright © 2022 Jiang, Sun, Hu, Zhang, Zhao, Shen, Yu, Huang, Li and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The ROC diagnostic analysis of biomarker panel (Imidazolepropionic acid, Erythronic acid, Homoserine, and Aspartic acid) for different groups. (B) Pathway analysis bubble plot by the Hsa set in KEGG. The x-axis is the pathway impact, indicating the importance of differentially expressed metabolites in metabolic pathways. The y-axis is the negative logarithm of p-value. The size of pathway symbols represents the statistical significance level of pathway analysis. The color of pathway symbols represents the impact factor. Large sizes and dark colors represent central pathway enrichment and high pathway impact values, respectively.