Figure 1.

CDG grade, KPS, and subsequent therapy (A): Of all 252 cases with any subsequent therapy, in 75 cases an AE prior to beginning of subsequent therapy was noted. The time to initiation and the CDG grade were correlated with Spearman’s rho = 0.13 (p = 0.038). The linear fit has a slope of 3.9 days per increment of CDG. (B): The occurrence of AE until 3 months postoperatively is associated with a significantly lower OS in Log Rank test (p < 0.001) (C): The occurrence of altered subsequent therapy is associated with a significantly lower OS in log-rank test (p < 0.001) (D): The subgroups with interruption or non-initiation of subsequent therapy had both a significant decreased OS (p < 0.001). The subgroup with delay showed no significant association with OS (p = 0.113).