Table 3.
Predictor of overall survival (OS).
| Prognostic factors of overall survival | ||||
|---|---|---|---|---|
| Variables | Coefficient Exp(B) | SE | 95% CI | p-value |
| Occurrence of AE from surgery to 3 months postoperatively | 1.32 | 0.15 | 0.99 - 1.77 | 0.063 |
| Altered subsequent therapy | 1.97 | 0.16 | 1.44 - 2.69 | < 0.001* |
| Age | 1.04 | 0.01 | 1.03-1.05 | < 0.001* |
| Male sex | 0.99 | 0.14 | 0.75-1.31 | 0.949 |
| Tumor grade (WHO grade) | 2.28 | 0.27 | 1.33-3.89 | 0.003* |
| Preoperative KPS | 0.99 | <0.01 | 0.98-0.99 | 0.003* |
| Extent of resection (reference category biopsy only) | ||||
| Partial resection | 0.65 | 0.16 | 0.47-0.90 | 0.008* |
| Gross total resection | 0.50 | 0.19 | 0.35-0.72 | < 0.001* |
| Unclear extent of resection | 0.79 | 0.36 | 0.39-1.59 | 0.514 |
The putative predicting factors for OS as AE and altered subsequent therapy were analyzed using a Cox proportional hazard model correcting for confounders. AE, adverse event; KPS, Karnofsky Performance Status; SE, standard error.
*Statistically significant. Prognostic factors of main interest are highlighted in bold.