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. 2022 Sep 23;13:1006376. doi: 10.3389/fendo.2022.1006376

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Copyright © 2022 Dinić, Arambašić Jovanović, Uskoković, Mihailović, Grdović, Tolić, Rajić, Đorđević and Vidaković

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of natural antioxidants in the regulation of epigenetic mechanisms involved in diabetes pathogenesis. Antioxidants are becoming powerful alternative approach in epigenetic therapy. Besides synthetic compounds as a potential epigenetic modifiers (Aza, Vidaza, Decitabine (DAC), valproic acid and trichostatin A), it has been shown that polyphenolic compounds have the ability to modulate epigenetic related mechanisms including DNA methylation, histone modification and regulation of miRNA expression. SAM, S-Adenosyl methionine; SAH, S-adenosylhomocysteine; DNMTs, DNA methyltransferases; HATs, Histone acetyltransferases; HDACs, Histone deacetylases; HMTs, Histone methyltransferases; RISC, RNA-induced silencing complex; EGCG, epigallocatechin gallate; W, writers of histone marks; R, readers of histone marks; E, erasers of histone marks.