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. 2022 Sep 28;10:1009908. doi: 10.3389/fcell.2022.1009908

TABLE 3.

Clinical significance and potential therapeutic implications of annexin dysregulation in human cancers.

Clinical and therapeutic relevance of annexins
Annexin Good prognosis Poor prognosis Diagnosis/Stratification Therapy resistance Potential targeted therapy
 ANXA1 Low: renal cancer Fu et al. (2020)
High: HER2+ BC; ESCC Paweletz et al. (2000)
Low: HNSCC Garcia Pedrero et al. (2004)
Low, HNSCC differentiation grading, detection of epithelial dysplasia Garcia Pedrero et al. (2004); low, OSCC blood biomarker Faria et al. (2010) ESCC Han et al. (2018); multiple myeloma Jia et al. (2018); NPC Huang et al. (2016) Ac 2-26 Cardin et al. (2019); Guan et al. (2019)
High: OC Fu et al. (2020)
 ANXA2 High: osteosarcoma Gillette et al. (2004) High: ESCC Ma et al. (2014); NPC Chen et al. (2015); NSLC; HCC; OC; BC Li et al. (2021b)
Low: HNSCC Rodrigo et al., 2011b. (2014), sinonasal adenocarcinoma Rodrigo et al. (2011a)
NPC Chen et al. (2015); BC Madureira et al. (2012); Grindheim et al. (2016) CLG-shANXA2 Andey et al. (2014); anti-ANXA2 antibodies Lokman et al. (2013); ANXA2-targeting peptide motif CBP12 Staquicini et al. (2017), Lm-ANXA2 Kim et al. (2019)
 ANXA3 High: GC; HCC; BC Liu et al. (2021a) Prostate cancer Schostak et al. (2009) HCC; OC; lung cancer; prostate cancer; BC; CRC Liu et al. (2021a)
 ANXA4 High: OSCC Liu et al. (2016a); OC Choi et al. (2013) OSCC lepcha et al. (2021) MESO Yamashita et al. (2012); NSCLC Gaudio et al. (2016); Zheng et al. (2018); Scala et al. (2021); OSCC Xiong et al. (2011); OC Morimoto et al. (2014)
 ANXA5 Positive: adult AML Niu et al. (2019) High: glioma Zhong et al. (2021); HCC Sun et al. (2018); bladder Wu et al. (2021); CRC Xue et al. (2009); CSCC Shapanis et al. (2021) NPC (Tang et al., 2012)
 ANXA6 Low: CC Sun et al. (2020); basal-like BC* Koumangoye et al. (2013)
High: PDA Leca et al. (2016)
CC (Lomnytska et al., 2010); esophageal adenocarcinoma (Zaidi et al., 2014); HCC (Meier et al., 2016); OC (Noreen et al., 2020) TNBC Koumangoye et al. (2013); Widatalla et al. (2019); Li et al. (2021a)
 ANXA7 High: GBM Hung and Howng. (2003) High: GC a Yuan et al. (2014); HCC Sun et al. (2009a); HCC Sun et al. (2009b); HER2- BC Srivastava et al. (2001a), Srivastava et al. (2004).
Low: prostate Srivastava et al. (2001a), Srivastava et al. (2004).
Melanoma less invasive subtypes Kataoka et al. (2000); HER2- BC Srivastava et al. (2004)
 ANXA8 High: GC Ma et al. (2020); pancreatic cancer Pimiento et al. (2015); OC Gou et al. (2019); Zhu et al. (2020); OSCC Oka et al. (2016) ER- basal-like DCIS subgroup Rossetti et al. (2016)
 ANXA9 High: CRC Miyoshi et al. (2014); Yu et al. (2018); BC Xiao et al. (2019); GC Zhou et al. (2021); OC Kou et al. (2021) HNSCC differentiation grading Salom et al. (2019) OC Kou et al. (2021)
 ANXA10 High: LUAD Yumura et al. (2022); GBM Xu et al. (2021); OC Wang et al. (2019); PDAC Ishikawa et al. (2022b); small bowel adenocarcinoma Ishikawa et al. (2021); PTC Liu et al. (2021b); CRC Bae et al. (2015); ESCC Kodaira et al. (2019); intrahepatic cholangiocarcinoma Shao et al. (2022); melanoma Zhang et al. (2021a)
Low: early GC Ishikawa et al. (2020); bladder Munksgaard et al. (2011); HCC Liu et al. (2002), HCC Liu et al. (2012)
Serrated neoplasia pathway in CRC Bae et al. (2015); specific biomarker for gastrointestinal and pancreatic adenocarcinomas Lu et al. (2013); PDA Zhu et al. (2017)
 ANXA11 High: bladder Yao et al. (2022) High: GC Hua et al. (2018); CRC Duncan et al. (2008); AML Song et al. (2022) Bladder cancer Wu et al. (2021) OC Song et al. (2007); mCRC Kim et al. (2011), Kim et al. (2013); Roh et al. (2016); AML Song et al. (2022)
 ANXA13 High: CRC Jiang et al. (2017); LUAD Xue et al. (2020)
a

Controversial.

Red: tumor-promoter role.

Green: tumor-suppressor role.

AD, Adenocarcinoma; AML, Acute myeloid leukemia; BC, Breast carcinoma; CC, Cervical cancer; CRC, Colorectal carcinoma; mCRC, metastatic colorectal carcinoma; CSCC, cutaneous squamous cell carcinoma; DCIS, Ductal carcinoma in situ; ESCC, Esophageal squamous cell carcinoma; ER, Estrogen receptor; GBM, Glioblastoma multiforme; CBP12, Colorectal cancer binding peptide; GC, Gastric cancer; CLG, Cationic ligand-guide; HCC, hepatocellular carcinoma; HER2+/−, human epidermal growth factor receptor 2; HNSCC, Head and neck squamous cell carcinoma; LUAD, Lung adenocarcinoma; MESO, Mesothelioma; NPC, Nasopharyngeal cancer; NSCLC, Non-small cell lung cancer; PDA, Pancreatic ductal adenocarcinoma; PTC, Papillary thyroid cancer; OC, Ovarian carcinoma; OSCC, Oral squamous cell carcinoma; TNBC, Triple-negative breast cancer.