Table 1.

Characteristics of the single nucleotide polymorphisms used as instrumental variables for plasma homocysteine and their association with intracranial aneurysm.

rsID	Gene	plasma Hcy level			IA (unruptured and ruptured)			Unruptured IA			Ruptured IA (aSAH)
		β	SE	p-value	β	SE	p-value	β	SE	p-value	β	SE	p-value
rs9369898	MUT	0.045	0.007	2.17E-10	−0.010	0.023	0.669	0.004	0.040	0.93	−0.016	0.027	0.56
rs7130284	NOX4	−0.124	0.013	1.88E-20	−0.020	0.040	0.609	−0.018	0.070	0.80	−0.017	0.046	0.72
rs4660306	MMACHC	0.044	0.007	2.33E-09	−0.004	0.023	0.868	−0.011	0.041	0.78	0.001	0.028	0.99
rs42648	GTPB10	−0.040	0.007	1.97E-08	−0.002	0.023	0.918	−0.004	0.040	0.91	−0.002	0.027	0.94
rs234709	CBS	−0.072	0.007	3.90E-24	−0.030	0.023	0.190	N/A	N/A	N/A	−0.022	0.026	0.39
rs2275565	MTR	−0.054	0.009	1.96E-10	−0.066	0.026	0.010	−0.058	0.047	0.22	−0.062	0.030	0.04
rs2251468	HNF1A	−0.051	0.007	1.28E-12	−0.019	0.022	0.390	−0.003	0.040	0.95	−0.021	0.025	0.39
rs1801222	CUBN	0.045	0.007	8.43E-10	0.017	0.022	0.431	0.029	0.041	0.48	0.010	0.025	0.70
rs1801133	MTHFR	0.158	0.007	4.34E-104	0.034	0.024	0.165	N/A	N/A	N/A	0.035	0.028	0.21
rs154657	DPEP1	0.096	0.007	1.74E-43	−0.018	0.023	0.434	0.008	0.040	0.83	−0.016	0.027	0.56
rs12780845	CUBN	0.053	0.009	7.80E-10	−0.007	0.024	0.780	0.005	0.042	0.91	−0.015	0.029	0.59

aSAH, aneurysmal subarachnoid hemorrhage; IA, intracranial aneurysm; Hcy, homocysteine.