Prognosis of patients after upfront surgery and NAC. Comparison of (A) OS and (B) DFS in patients with clinical stage III gastric cancer who underwent upfront surgery (n=146) and NAC followed by surgery (n=14). The OS and DFS times were calculated from the date of surgery to the date of death of any cause, recurrence, or the last follow-up. OS and DFS were estimated using the Kaplan-Meier method. NAC, neoadjuvant chemotherapy; OS, overall survival; DFS, disease free survival.