Table 4.
Binomial negative regression models to identify factors associated with the subclinical carotid atherosclerosis burden in subjects with T1D.
| Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|
| Predictors | IRR | 95% CI | IRR | 95% CI | IRR | 95% CI |
| α-klotho (log scale) | 1.40 * | 1.06–1.86 | 1.41 * | 1.06–1.89 | 1.41 * | 1.06–1.89 |
| Sex (women) | 0.57 | 0.33–0.97 | 0.54 * | 0.31–0.95 | 0.55 * | 0.31–0.97 |
| Age | 1.08 ‡ | 1.05–1.11 | 1.08 ‡ | 1.05–1.11 | 1.08 ‡ | 1.05–1.11 |
| sBP | 1.00 | 0.98–1.01 | 1.00 | 0.99–1.01 | 1.00 | 0.99–1.01 |
| BMI | 1.04 | 0.98–1.11 | 1.04 | 0.98–1.11 | 1.04 | 0.98–1.11 |
| Smoker | 2.39 † | 1.37–4.22 | 2.28 † | 1.29–4.07 | 2.29 † | 1.28–4.13 |
| Former smoker | 0.96 | 0.49–1.82 | 0.98 | 0.51–1.85 | 1.00 | 0.52–1.88 |
| Hypertension | 1.71 | 0.98–3.02 | 1.65 | 0.93–2.93 | 1.65 | 0.93–2.92 |
| Dyslipidemia | 1.53 | 0.93–2.55 | 1.62 | 0.95–2.80 | 1.60 | 0.94–2.77 |
| ACR | 1.01 ‡ | 1.00-1.02 | 1.02 † | 1.01–1.03 | 1.02 † | 1.00-1.03 |
| Calcium | 0.93 | 0.47–1.88 | 0.95 | 0.47–1.94 | ||
| Phosphate | 1.15 | 0.73–1.83 | 1.13 | 0.71–1.81 | ||
| PTH | 0.94 | 0.80–1.10 | 0.93 | 0.79–1.10 | ||
| FGF23 | 1.00 | 1.00–1.00 | ||||
| Vitamin D | 1.00 | 0.98–1.01 | ||||
| Observations | 225 | 225 | 225 | |||
| R2 Nagelkerke | 0.574 | 0.578 | 0.580 | |||
Association measure expressed by Incidence rate ratio (IRR) and 95% confidence interval (95% CI). ACR, Albuminuria-to-creatinine ratio; BMI, body mass index; FGF23, fibroblastic growth factor 23; PTH, parathyroid hormone; sBP, systolic blood pressure; Vitamin D, 25-hydroxyvitamin D
* p < 0.05; † p < 0.01; ‡ p < 0.001