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HPV8 E6 allows transcription and replication of DNA in micronuclei without membranes. (A to C) Percentages of iHFK cells with acetylated H3K27-positive (A), 53bp1-positive (B), and BrdU-positive (C) micronuclei. At least 150 micronuclei/cell line were quantified across three independent experiments. Graphs depict means ± the standard errors of the mean. Asterisks denote significant differences relative to LXSN (*, P ≤ 0.05 [Student t test]). MN, micronuclei.
