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H19 associated mechanisms towards tumorigenesis. ① PRC2 consists of core components (EZH2/EZH1, EED, SUZ12). ② H19 binds SAHH or MBD1 to promote the methylation of imprinted genes. ③ 91H and HOTS are the antisense transcripts of H19. ④ p53, E2F1 and eIF4A3, HIF1α can directly interact with H19 to affect tumorigenesis. ⑤ H19 is the precursor of miR-675. ⑥ H19 acts on post-transcriptional control as ceRNA.
