Table 2.
The detail of hub genes.
| No. | Gene symbol | Full name | Function |
|---|---|---|---|
| 1 | IL1B | Interleukin 1 beta | This cytokine is an important mediator of the inflammatory response and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. |
| 2 | IL10 | Interleukin 10 | This cytokine has pleiotropic effects in immunoregulation and inflammation. This cytokine can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. |
| 3 | CXCL10 | C-X-C motif chemokine ligand 10 | This cytokine has pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. |
| 4 | ICAM1 | Intercellular adhesion molecule 1 | This gene encodes a cell surface glycoprotein, which is typically expressed on endothelial cells and cells of the immune system. |
| 5 | EGR1 | Early growth response 1 | The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. |
| 6 | FCGR3A | Fc gamma receptor IIIa | This gene is involved in the removal of antigen–antibody complexes from the circulation, as well as other responses, including antibody-dependent cellular-mediated cytotoxicity and antibody-dependent enhancement of virus infections. |
| 7 | S100A12 | S100 calcium-binding protein A12 | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and stress fibers, suggesting diverse functions in signal transduction. |
| 8 | S100A9 | S100 calcium-binding protein A9 | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. This protein may function in the inhibition of casein kinase, and altered expression of this protein is associated with the disease cystic fibrosis. |
| 9 | FPR1 | Formyl peptide receptor 1 | This gene encodes a G protein-coupled receptor of mammalian phagocytic cells. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation |