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. 2022 Oct 10;17:4725–4741. doi: 10.2147/IJN.S381170

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© 2022 Chen et al.

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In vivo tumor targeting and circulation prolonging ability of M1/IR780@PLGA nanoparticles. (A) In vivo fluorescence imaging and (B) intensities of tumor-bearing mice at 4, 12, 24, 48, 72h after intravenous injection of M1/IR780@PLGA nanoparticles or IR780@PLGA nanoparticles. (C) Averaged ex vivo NIR fluorescence intensities at 72h and (D) NIR fluorescence images of major organs. (E) TEM images of tumor tissue at 72h, the red arrows indicated the nanocarbon labeled nanoparticles. Data are expressed as means SD (n = 3). Statistical significances were calculated via Student’s t-test, *P < 0.05, ***P< 0.001.