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. Author manuscript; available in PMC: 2022 Oct 12.
Published in final edited form as: Lab Chip. 2019 Jan 15;19(2):306–315. doi: 10.1039/c8lc00825f

Fig. 1: The design principle of the NOA81 O2 mask.

Fig. 1:

a) Layout of a hybrid device used to generate a circular region of hypoxia. (Note: reservoir with oxygen scavenger is not shown). b) Cross-sectional view of the microfluidic device comprised of NOA81 and PDMS (not drawn to scale). Blue and red colors show oxygen scavenging chemical (PYR) and air, respectively. Air channels are used to contain and confine oxygen depletion zone. c) An image of features microfabricated in NOA81 layer and used for defining where oxygen scavenging chemical comes in contact with the underlying PDMS layer. d) COMSOL numerical simulation of the oxygen transport inside the PDMS film. e) A section view of the oxygen distribution on a slice passing the center of the circle.