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. 2022 Oct 12;130(10):107002. doi: 10.1289/EHP10255

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Figure 8 is a set of five bar graphs titled tumor necrosis factor alpha, monocyte chemoattractant protein-1, interleukin-6, interleukin-1 lowercase beta, and chemokine ligand 10, plotting Messenger Ribonucleic acid levels (relative unit), ranging from 0 to 20 in increments of 5; 0 to 20 in increments of 5; 0.0 to 1.5 in increments of 0.5; 0 to 5 in unit increments; and 0 to 10 in increments of 2 (y-axis) across control, 0.5 micrometer with 100 and 1,000, 4 micrometers with 100 and 1,000, and 10 micrometers with 100 and 1,000 (x-axis), respectively. — mRNA expression of proteins related to inflammation in the hippocampus of polystyrene microplastics (PS-MPs)–treated mice. The levels of tumor necrosis factor alpha ( $T n f - α$ ), $interleukin – 1 lowercase beta$ ( $uppercase italic i lowercase italic l – 1 lowercase italic beta$ ), interleukin-6 (Il-6), chemokine (C-X-C motif) ligand 10 (Cxcl10), and monocyte chemoattractant protein-1 (Mcp-1) in the hippocampus were measured via qRT-PCR. Data are expressed as the $means \pm SDs$ for three independent experiments ( $uppercase italic n equals 3$ mice/group). The mean and SD summary data for quantification are shown in Table S3. $p$ -Values for all comparisons are reported in Table S4. * $lowercase italic p less than 0.05$ ; ** $lowercase italic p less than 0.01$ vs. control, as detected by one-way ANOVA followed by Dunnett’s multiple comparison tests. Note: ANOVA, analysis of variance; qRT-PCT, quantitative real-time polymerase chain reaction; SD, standard deviation.