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. 2022 Oct 12;17(10):e0266861. doi: 10.1371/journal.pone.0266861

Fig 2. Analysis of motor function and anxiety in FoxG1MUT/WT mice.

Fig 2

A) Foxg1MUT/WT mice (MUT) do not show any changes on the accelerating rotating rod task compared to wild-type (WT) littermate controls (10 weeks old, n = 15 for each genotype). B-E: Open Field Assay (OFA, 8–11 weeks, WT n = 26, MUT n = 31). MUT animals have decreased overall distance traveled (B, F[1,54] = 7.885, p = 0.007, corrected p = 0.037, η2 = 0.127) and vertical counts (C, F[1,54] = 6.592, p = 0.012, corrected p = 0.040, η2 = 1.09). MUT animals spend less percentage time in center area (D, F[1,54] = 6.991, p = 0.011, corrected p = 0.046, η2 = 0.115) and travel less percentage distance traveled in the center area (E, F[1,54] = 53.193, p<0.001, corrected p<0.001, η2 = 0.496) in OFA. F-G: Elevated Zero Maze (EZM, 20wks, WT n = 11, MUT = 14). MUT animals did not show any difference in the percent time spent in the open arm (F, F[1,22] = 1.027, p = 0.322, corrected p = 0.446) but traveled more percentage distance in the open arm (G, F[1,22] = 9.838, p = 0.005, corrected p = 0029, η2 = 0.322). Uncorrected p-values: *p<0.05, *p<0.01, ***P<0.001.