Fig 4. Foxg1^MUT/WT mice show changes in compulsive and social behavior tests.

A) Foxg1^MUT/WT mice (MUT, n = 15) have a decreased percentage of marbles buried in the marble burying task compared to WT (n = 15) at 13 weeks (F[1,27] = 4.782, p = 0.038, corrected p = 0.085, η² = 0.150). B) MUT (n = 15) mice show increased average number of wins (over 2 bouts) compared to WT (n = 15) at 13 weeks (F[1,27] = 7.105, p = 0.013, corrected p = 0.042, η² = 0.208) in the tube test assay. At 15 weeks old, MUT (n = 15) animals had a decreased next building score (C, F[1,27] = 6.576, p = 0.016, corrected p = 0.046, η² = 0.196) and trended towards a decreased percentage of nestlet shredding (D, F[1,27] = 4.035, p = 0.055, corrected p = 0.102) compared to WT (n = 15) animals. E) MUT mice (n = 16) have changes in social behavior on the 3-chamber task at 9 weeks compared to WT (n = 11) mice. MUT animals trended to have increased Social Index in close proximity to cup with stranger mouse (F[1,24] = 4.071, p = 0.055, corrected p = 0.098) and significant increase in Social Index of time in chamber with stranger mouse (F[1,24] = 4.684, p = 0.041, corrected p = 0.083, η² = 0.163). In contrast, MUT mice spent more time with a familiar mouse than a new stranger mouse (Novelty Index), with a trend towards less Novelty Index to cup compared to WT mice (F[1,24] = 3.201, p = 0.086 corrected p = 0.143) and significant decreased Novelty Index compared to WT mice in the chamber (F[1,24] = 4.905, p = 0.037, corrected p = 0.087, η² = 0.170). #p<0.1, *p<0.05.