Table 3. Volumetric assessment of Foxg1MUT/WT mice using MRI.
ROI | Group | Mean-no WBV | SD-no WBV | p-value no WBV | Mean-WBV Corrected | SD-WBV Corrected | p-value# |
---|---|---|---|---|---|---|---|
Whole Brain Volume (WBV) | WT | 150.8333 | 4.92875 | * .00662 | -- | -- | -- |
HET | 138.1869 | 7.2541 | |||||
Total | 144.5101 | 8.86447 | |||||
Lateral Ventricle | WT | 1.65265 | 0.20841 | * .00578 | 0.01095 | 0.0013 | 0.02207 |
HET | 1.27545 | 0.05663 | 0.00925 | 0.00057 | |||
Total | 1.46405 | 0.24496 | 0.0101 | 0.00131 | |||
Intraventricular Foramen | WT | 0.0039 | 0.00306 | 0.14837 | 0.00003 | 0.00002 | 0.1668 |
HET | 0.00173 | 0.00093 | 0.00001 | 0.00001 | |||
Total | 0.00282 | 0.00243 | 0.00002 | 0.00002 | |||
Hippocampus | WT | 6.47802 | 0.18381 | * .00371 | 0.04297 | 0.00126 | 0.70867 |
HET | 5.90553 | 0.29944 | 0.04274 | 0.00066 | |||
Total | 6.19178 | 0.38144 | 0.04286 | 0.00096 | |||
Olfactory System | WT | 24.58858 | 1.01571 | * .00226 | 0.16316 | 0.0084 | 0.63568 |
HET | 22.28573 | 0.94077 | 0.16136 | 0.00275 | |||
Total | 23.43716 | 1.52235 | 0.16226 | 0.00603 | |||
Basal Ganglia | WT | 9.13177 | 0.58828 | * .00425 | 0.0605 | 0.0024 | 0.0478 |
HET | 7.98298 | 0.47336 | 0.05777 | 0.00167 | |||
Total | 8.55738 | 0.78681 | 0.05914 | 0.00243 | |||
Olfactory Nerve | WT | 0.00073 | 0.00054 | 0.55723 | 0 | 0 | 0.76566 |
HET | 0.00057 | 0.0004 | 0 | 0 | |||
Total | 0.00065 | 0.00046 | 0 | 0 | |||
Corpus Callosum | WT | 12.3984 | 0.42803 | * .00174 | 0.08221 | 0.00148 | *.00109 |
HET | 10.65882 | 0.79888 | 0.07707 | 0.00219 | |||
Total | 11.52861 | 1.09485 | 0.07964 | 0.00322 | |||
Anterior Commissure Olfactory Limb | WT | 0.64525 | 0.04162 | 0.09611 | 0.00428 | 0.00029 | 0.79429 |
HET | 0.58655 | 0.06466 | 0.00424 | 0.00029 | |||
Total | 0.6159 | 0.06023 | 0.00426 | 0.00028 | |||
Lateral Olfactory Tract | WT | 1.36563 | 0.08943 | 0.04843 | 0.00907 | 0.00079 | 0.45808 |
HET | 1.20957 | 0.13989 | 0.00874 | 0.0007 | |||
Total | 1.2876 | 0.13846 | 0.0089 | 0.00073 | |||
Internal Capsule | WT | 3.91435 | 0.19739 | * .00437 | 0.02594 | 0.00058 | 0.01408 |
HET | 3.46397 | 0.22565 | 0.02505 | 0.00043 | |||
Total | 3.68916 | 0.31012 | 0.0255 | 0.00067 | |||
Anterior Commissure Temp Limb | WT | 0.47452 | 0.00716 | 0.27234 | 0.00315 | 0.00007 | * .00121 |
HET | 0.46288 | 0.02247 | 0.00335 | 0.00008 | |||
Total | 0.4687 | 0.01702 | 0.00325 | 0.00013 | |||
Stria Terminalis | WT | 0.00108 | 0.00091 | 0.47036 | 0.00001 | 0.00001 | 0.35297 |
HET | 0.00142 | 0.00058 | 0.00001 | 0 | |||
Total | 0.00125 | 0.00075 | 0.00001 | 0.00001 | |||
Amygdala | WT | 0.8005 | 0.02179 | * .00066 | 0.00531 | 0.00012 | * .00292 |
HET | 0.6532 | 0.05519 | 0.00473 | 0.00029 | |||
Total | 0.72685 | 0.08671 | 0.00502 | 0.00037 | |||
Hypothalamus | WT | 9.64162 | 0.3497 | 0.14864 | 0.06392 | 0.001 | 0.00811 |
HET | 9.25945 | 0.47951 | 0.06703 | 0.00189 | |||
Total | 9.45053 | 0.44714 | 0.06548 | 0.00217 | |||
Thalamus | WT | 18.01777 | 0.67212 | * .00630 | 0.11945 | 0.00207 | 0.27956 |
HET | 16.30582 | 0.97022 | 0.11798 | 0.00238 | |||
Total | 17.16179 | 1.19688 | 0.11872 | 0.00226 | |||
Fasciculus Retroflexus | WT | 0.07788 | 0.00882 | 0.09664 | 0.00052 | 0.00005 | 0.79877 |
HET | 0.07015 | 0.00471 | 0.00051 | 0.00004 | |||
Total | 0.07402 | 0.00786 | 0.00051 | 0.00004 | |||
Stria Medullaris | WT | 0.29677 | 0.01387 | 0.02382 | 0.00197 | 0.00006 | 0.39622 |
HET | 0.26662 | 0.02284 | 0.00193 | 0.00009 | |||
Total | 0.28169 | 0.02392 | 0.00195 | 0.00008 | |||
Midbrain | WT | 14.497 | 0.67974 | * .00619 | 0.0961 | 0.00265 | 0.84772 |
HET | 13.31745 | 0.38658 | 0.09656 | 0.00508 | |||
Total | 13.90723 | 0.81081 | 0.09633 | 0.00387 | |||
Hindbrain | WT | 0.00082 | 0.00056 | 0.67908 | 0.00001 | 0 | 0.79939 |
HET | 0.00068 | 0.00052 | 0 | 0 | |||
Total | 0.00075 | 0.00052 | 0.00001 | 0 | |||
Pons | WT | 26.39558 | 1.07066 | 0.07458 | 0.17496 | 0.00172 | * .00049 |
HET | 25.12625 | 1.1367 | 0.1819 | 0.00262 | |||
Total | 25.76092 | 1.2441 | 0.17843 | 0.00419 | |||
Medulla | WT | 14.43622 | 1.172 | 0.32998 | 0.09564 | 0.0059 | 0.49559 |
HET | 13.6141 | 1.56915 | 0.09827 | 0.00693 | |||
Total | 14.02516 | 1.38848 | 0.09696 | 0.00629 | |||
Fornix System | WT | 4.49635 | 0.24178 | 0.07291 | 0.02981 | 0.00136 | 0.41149 |
HET | 4.20985 | 0.25323 | 0.03048 | 0.00133 | |||
Total | 4.3531 | 0.27947 | 0.03015 | 0.00133 | |||
Pituitary | WT | 1.51792 | 0.2617 | 0.94945 | 0.01005 | 0.00158 | 0.3395 |
HET | 1.52813 | 0.28226 | 0.01102 | 0.00176 | |||
Total | 1.52303 | 0.25956 | 0.01053 | 0.00167 |
#controlling for WBV
*FDR corrected, p < .05.